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Increased Cerebral ...
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Marklund, NiklasUppsala universitet,Neurokirurgi
(författare)
Increased Cerebral Uptake of [18F]Fluoro-Deoxyglucose but not [1-14C]Glucose Early following Traumatic Brain Injury in Rats
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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Mary Ann Liebert Inc,2009
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-120848
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120848URI
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https://doi.org/10.1089/neu.2008.0827DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Following experimental and clinical traumatic brain injury (TBI), the local cerebral metabolic rate of glucose (lCMRGlc) is commonly estimated using the 2-[18F]fluoro-2-deoxy-D-glucose (FDG) method. The adequate estimation of lCMRGlc using FDG requires a correction factor, the lumped constant (LC), to convert FDG net uptake into lCMRGlc. The LC, and thus lCMRGlc calculations, requires a "steady state" that may be disrupted following TBI. In the present report, we hypothesized that [1-14C]glucose uptake would accurately reflect glucose dynamics early post-injury and was compared to the regional uptake of FDG in 44 rats subjected to moderate (2.4-2.6 atm) lateral fluid percussion brain injury (FPI) or sham injury. Cortical energy state and adenylate (ATP, ADP, AMP) levels were also measured. Early (7-42 min) after FPI, FDG uptake was increased in the ipsilateral cortex and hippocampus (p<0.05). In contrast, no change in [1-14C]glucose uptake (7 and 17 min) or cortical adenylate content (42 min post-injury) was observed. At 12 hours following FPI, the ipsilateral FDG and [1-14C]glucose uptake was decreased in the cortex and hippocampus and the ipsilateral cortical ATP concentration was decreased in comparison to sham-injured controls (p<0.05). Under the present experimental conditions, the rate of cerebral uptake of FDG and of [1-14C]glucose differs, and indicate that following TBI, regional changes in the LC may occur in the immediate, but not in the late, post-injury phase. These results should be considered when interpreting results obtained using FDG for the estimation of lCMRGlc early following experimental TBI.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sihver, SvenUppsala universitet,Institutionen för biokemi och organisk kemi,Farmakologi
(författare)
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Hovda, David
(författare)
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Långström, BengtUppsala universitet,Institutionen för biokemi och organisk kemi(Swepub:uu)benglang
(författare)
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Watanabe, Yasuyoshi
(författare)
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Ronquist, GunnarUppsala universitet,Klinisk kemi(Swepub:uu)guron517
(författare)
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Bergström, MatsUppsala universitet,Institutionen för biokemi och organisk kemi
(författare)
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Hillered, LarsUppsala universitet,Neurokirurgi(Swepub:uu)larshill
(författare)
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Uppsala universitetNeurokirurgi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Neurotrauma: Mary Ann Liebert Inc26:8, s. 1281-12930897-71511557-9042
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