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Prognostic value of...
Prognostic value of reading-to-reading blood pressure variability over 24 hours in 8938 subjects from 11 populations
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Hansen, Tine W. (författare)
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Thijs, Lutgarde (författare)
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Li, Yan (författare)
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Boggia, José (författare)
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Kikuya, Masahiro (författare)
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- Björklund-Bodegård, Kristina (författare)
- Uppsala universitet,Geriatrik
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Richart, Tom (författare)
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Ohkubo, Takayoshi (författare)
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Jeppesen, Jørgen (författare)
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Torp-Pedersen, Christian (författare)
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Dolan, Eamon (författare)
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Kuznetsova, Tatiana (författare)
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Stolarz-Skrzypek, Katarzyna (författare)
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Tikhonoff, Valérie (författare)
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Malyutina, Sofia (författare)
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Casiglia, Edoardo (författare)
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Nikitin, Yuri (författare)
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- Lind, Lars (författare)
- Uppsala universitet,Geriatrik
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Sandoya, Edgardo (författare)
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Kawecka-Jaszcz, Kalina (författare)
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Imai, Yutaka (författare)
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Wang, Jiguang (författare)
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Ibsen, Hans (författare)
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O'Brien, Eoin (författare)
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Staessen, Jan A. (författare)
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(creator_code:org_t)
- 2010
- 2010
- Engelska.
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Ingår i: Hypertension. - 0194-911X .- 1524-4563. ; 55:4, s. 1049-1057
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In previous studies, of which several were underpowered, the relation between cardiovascular outcome and blood pressure (BP) variability was inconsistent. We followed health outcomes in 8938 subjects (mean age: 53.0 years; 46.8% women) randomly recruited from 11 populations. At baseline, we assessed BP variability from the SD and average real variability in 24-hour ambulatory BP recordings. We computed standardized hazard ratios (HRs) while stratifying by cohort and adjusting for 24-hour BP and other risk factors. Over 11.3 years (median), 1242 deaths (487 cardiovascular) occurred, and 1049, 577, 421, and 457 participants experienced a fatal or nonfatal cardiovascular, cardiac, or coronary event or a stroke. Higher diastolic average real variability in 24-hour ambulatory BP recordings predicted (Por=1.07) with the exception of cardiac and coronary events (HR: or=0.58). Higher systolic average real variability in 24-hour ambulatory BP recordings predicted (P<0.05) total (HR: 1.11) and cardiovascular (HR: 1.16) mortality and all fatal combined with nonfatal end points (HR: >or=1.07), with the exception of cardiac and coronary events (HR: or=0.54). SD predicted only total and cardiovascular mortality. While accounting for the 24-hour BP level, average real variability in 24-hour ambulatory BP recordings added <1% to the prediction of a cardiovascular event. Sensitivity analyses considering ethnicity, sex, age, previous cardiovascular disease, antihypertensive treatment, number of BP readings per recording, or the night:day BP ratio were confirmatory. In conclusion, in a large population cohort, which provided sufficient statistical power, BP variability assessed from 24-hour ambulatory recordings did not contribute much to risk stratification over and beyond 24-hour BP.
Nyckelord
- Ambulatory blood pressure
- Blood pressure variability
- Epidemiology
- Population science
- Risk factors
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Hansen, Tine W.
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Thijs, Lutgarde
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Li, Yan
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Boggia, José
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Kikuya, Masahiro
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Björklund-Bodegå ...
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visa fler...
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Richart, Tom
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Ohkubo, Takayosh ...
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Jeppesen, Jørgen
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Torp-Pedersen, C ...
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Dolan, Eamon
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Kuznetsova, Tati ...
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Stolarz-Skrzypek ...
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Tikhonoff, Valér ...
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Malyutina, Sofia
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Casiglia, Edoard ...
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Nikitin, Yuri
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Lind, Lars
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Sandoya, Edgardo
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Kawecka-Jaszcz, ...
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Imai, Yutaka
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Wang, Jiguang
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Ibsen, Hans
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O'Brien, Eoin
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Staessen, Jan A.
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visa färre...
- Artiklar i publikationen
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Hypertension
- Av lärosätet
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Uppsala universitet