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The impact of birth...
The impact of birth weight on prostate cancer incidence and mortality in a population-based study of men born in 1913 and followed up from 50 to 85 years of age
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- Eriksson, Margaretha, 1951- (författare)
- Uppsala universitet,Allmänmedicin och klinisk epidemiologi
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- Wedel, Hans (författare)
- Nordic School of Public Health, Gothenburg
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- Wallander, Mari-Ann (författare)
- Uppsala universitet,Allmänmedicin och klinisk epidemiologi
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- Krakau, Ingvar (författare)
- Karolinska Institutet
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- Hugosson, Jonas, 1955 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Carlsson, Sture (författare)
- Department of Surgery, Kungälv Hospital
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- Svärdsudd, Kurt (författare)
- Uppsala universitet,Allmänmedicin och klinisk epidemiologi
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(creator_code:org_t)
- 2007
- 2007
- Engelska.
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Ingår i: The Prostate. - : Wiley. - 0270-4137 .- 1097-0045. ; 67:11, s. 1247-1254
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Insulin-like growth factor-I (IGF-I) hormone is directly associated with birth weight (BW), and high IGF-I measured in adults is associated with increased risk of prostate cancer (PCA). Whether BW and PCA are related is inconclusive to date. METHODS: BW and PCA incidence and mortality data for a population-based cohort of 1,436 singleton Swedish men born in 1913 and followed until 85 years of age were obtained. RESULTS: BW > or = 4,250 g was associated with significantly higher PCA incidence [62% (CI: 4%-151%)] and PCA mortality [82% (CI: 3%-221%)] than BW 3,001-4,249 g, even when other potential effect modifiers were taken into account. The hazards ratio for PCA incidence fell from approximately 3 at age 50 to unity at age 85. Approximately one out of every six PCA incident cases between 50 and 70 years of age could be attributed to BW > or = 4,250 g. CONCLUSIONS: In the current study PCA incidence and mortality rate appears to increase with BW.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Birth weight
- Cohort studies
- Follow-up studies
- Prostate cancer
- MEDICINE
- MEDICIN
- birth weight • prostate cancer • cohort studies • follow-up studies
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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