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Catecholamine-induc...
Catecholamine-induced excitation of nociceptors in sympathetically maintained pain
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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Ovid Technologies (Wolters Kluwer Health),2007
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-14196
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-14196URI
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https://doi.org/10.1016/j.pain.2006.08.022DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:13945716URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Sympathetically maintained pain could either be mediated by ephaptic interactions between sympathetic efferent and afferent nociceptive fibers or by catecholamine-induced activation of nociceptive nerve endings. We report here single fiber recordings from C nociceptors in a patient with sympathetically maintained pain, in whom sympathetic blockade had repeatedly eliminated the ongoing pain in both legs. We classified eight C-fibers as mechano-responsive and six as mechano-insensitive nociceptors according to their mechanical responsiveness and activity-dependent slowing of conduction velocity (latency increase of 0.5±1.1 vs. 7.1±2.0ms for 20 pulses at 0.125Hz). Two C-fibers were activated with a delay of several seconds following strong endogenous sympathetic bursts; they were also excited for about 3min following the injection of norepinephrine (10μl, 0.05%) into their innervation territory. In these two fibers, a prolonged activation by injection of low pH solution (phosphate buffer, pH 6.0, 10μl) and sensitization of their heat response following prostaglandin E2 injection were recorded, evidencing their afferent nature. Moreover, their activity-dependent slowing was typical for mechano-insensitive nociceptors. We conclude that sensitized mechano-insensitive nociceptors can be activated by endogenously released catecholamines and thereby may contribute to sympathetically maintained pain. No evidence for ephaptic interaction between sympathetic efferent and nociceptive afferent fibers was found.
Ämnesord och genrebeteckningar
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Nociception
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Hyperalgesia
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Sensitisation
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Cathecholamines
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Sympathetically maintained pain
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Örstavik, K.
(författare)
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Schmidt, RolandUppsala universitet,Klinisk neurofysiologi(Swepub:uu)rolaschm
(författare)
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Namer, Berit
(författare)
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Carr, R. W.
(författare)
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Kvarstein, G.
(författare)
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Hilliges, M.
(författare)
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Handwerker, H.
(författare)
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Torebjörk, ErikUppsala universitet,Klinisk neurofysiologi(Swepub:uu)eto03183
(författare)
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Schmelz, M.
(författare)
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Uppsala universitetKlinisk neurofysiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Pain: Ovid Technologies (Wolters Kluwer Health)127:3, s. 296-3010304-39591872-6623
Internetlänk
Hitta via bibliotek
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Pain
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Till lärosätets databas
- Av författaren/redakt...
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Jörum, E.
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Örstavik, K.
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Schmidt, Roland
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Namer, Berit
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Carr, R. W.
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Kvarstein, G.
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visa fler...
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Hilliges, M.
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Handwerker, H.
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Torebjörk, Erik
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Schmelz, M.
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visa färre...
- Artiklar i publikationen
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Pain
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet