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Demonstration of im...
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Bergquist, JonasDepartment of Clinical Neuroscience, Section of Psychiatry and Neurochemistry, University of Göteborg
(författare)
Demonstration of immunoglobulin G with affinity for dopamine in cerebrospinal fluid from psychotic patients.
- Artikel/kapitelEngelska1993
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LIBRIS-ID:oai:DiVA.org:uu-150345
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150345URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Using an enzyme-linked immunosorbent assay, significantly raised concentrations of immunoglobulin G with affinity for the neurotransmitter dopamine were demonstrated in cerebrospinal fluid from psychotic patients. We have varied the antigen presentation in order to find a conjugate with low unspecific binding. The conjugation of dopamine to carbodiimide-activated poly-L-glutamic acid and that to activated succinimide ester of biotin are described. The use of glutaraldehyde conjugation is not recommended because of the risk of formation of tetrahydroisoquinolines. A strong correlation (r = 0.94, P < 0.001) between the results obtained with dopamine conjugated to poly-L-glutamic acid and dopamine conjugated to biotin was observed. Forty-two human cerebrospinal fluid samples from 20 psychotic patients, (12 with a bipolar disorder and 8 with schizophrenia) and 22 control patients, with various neurological diseases but no apparent psychiatric diseases were investigated. A significantly higher incidence (P < 0.001) of antibodies with affinity for dopamine were found in the group of psychotic patients compared with the neurological control group.
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Bergquist, SDepartment of Psychiatry and Neurochemistry, University of Lund
(författare)
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Axelsson, RDepartment of Psychiatry, Sahlgren Hospital, University of Göteborg
(författare)
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Ekman, RDepartment of Clinical Neuroscience, Section of Psychiatry and Neurochemistry, University of Göteborg
(författare)
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Department of Clinical Neuroscience, Section of Psychiatry and Neurochemistry, University of GöteborgDepartment of Psychiatry and Neurochemistry, University of Lund
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinica Chimica Acta217:2, s. 129-420009-89811873-3492
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