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The Myeloproliferat...
The Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) : International Prospective Validation and Reliability Trial in 402 patients
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Scherber, Robyn (författare)
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Dueck, Amylou C. (författare)
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Johansson, Peter (författare)
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Barbui, Tiziano (författare)
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Barosi, Giovanni (författare)
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Vannucchi, Alessandro M. (författare)
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Passamonti, Francesco (författare)
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Andreasson, Bjorn (författare)
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Ferarri, Maria L. (författare)
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Rambaldi, Alessandro (författare)
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- Samuelsson, Jan (författare)
- Karolinska Institutet
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- Birgegård, Gunnar (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Hermatology
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Tefferi, Ayalew (författare)
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Harrison, Claire N. (författare)
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Radia, Deepti (författare)
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Mesa, Ruben A. (författare)
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(creator_code:org_t)
- American Society of Hematology, 2011
- 2011
- Engelska.
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 118:2, s. 401-408
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Symptomatic burden in myeloproliferative neoplasms is present in most patients and compromises quality of life. We sought to validate a broadly applicable 18-item instrument (Myeloproliferative Neoplasm Symptom Assessment Form [MPN-SAF], coadministered with the Brief Fatigue Inventory) to assess symptoms of myelofibrosis, essential thrombocythemia, and polycythemia vera among prospective cohorts in the United States, Sweden, and Italy. A total of 402 MPN-SAF surveys were administered (English [25%], Italian [46%], and Swedish [28%]) in 161 patients with essential thrombocythemia, 145 patients with polycythemia vera, and 96 patients with myelofibrosis. Responses among the 3 administered languages showed great consistency after controlling for MPN subtype. Strong correlations existed between individual items and key symptomatic elements represented on both the MPN-SAF and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-C30. Enrolling physicians' blinded opinion of patient symptoms (6 symptoms assessed) were highly correlated with corresponding patients' responses. Serial administration of the English MPN-SAF among 53 patients showed that most MPN-SAF items are well correlated (r > 0.5, P < .001) and highly reproducible (intraclass correlation coefficient > 0.7). The MPN-SAF is a comprehensive and reliable instrument that is available in multiple languages to evaluate symptoms associated with all types of MPNs in clinical trials globally.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Blood
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- Av författaren/redakt...
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Scherber, Robyn
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Dueck, Amylou C.
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Johansson, Peter
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Barbui, Tiziano
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Barosi, Giovanni
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Vannucchi, Aless ...
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visa fler...
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Passamonti, Fran ...
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Andreasson, Bjor ...
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Ferarri, Maria L ...
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Rambaldi, Alessa ...
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Samuelsson, Jan
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Birgegård, Gunna ...
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Tefferi, Ayalew
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Harrison, Claire ...
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Radia, Deepti
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Mesa, Ruben A.
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visa färre...
- Artiklar i publikationen
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Blood
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet