Sökning: onr:"swepub:oai:DiVA.org:uu-159724" > Intragraft Cytomega...
Fältnamn | Indikatorer | Metadata |
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000 | 03695naa a2200445 4500 | |
001 | oai:DiVA.org:uu-159724 | |
003 | SwePub | |
008 | 111007s2011 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:123439016 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1597242 URI |
024 | 7 | a https://doi.org/10.1093/cid/cir6192 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1234390162 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Dzabic, Mensuru Karolinska Institutet4 aut |
245 | 1 0 | a Intragraft Cytomegalovirus Protein Expression Is Associated With Reduced Renal Allograft Survival |
264 | c 2011-09-29 | |
264 | 1 | b Oxford University Press (OUP),c 2011 |
338 | a print2 rdacarrier | |
520 | a Background: Cytomegalovirus (CMV) infection is a risk factor for acute and chronic rejection of transplanted organs and is thought to mediate rejection indirectly. Methods: In this retrospective observational cohort study, early- and end-stage biopsies from renal allografts lost because of chronic allograft dysfunction (n = 29) were examined for CMV antigens and DNA using immunohistochemistry, in situ hybridization, and real-time polymerase chain reaction. Results: CMV immediate-early and late proteins were present in 27 (93%) of 29 of the end-stage chronic allograft dysfunction biopsies and in 64% of the corresponding early biopsies but not in pretransplant biopsies from CMV-seronegative donors (n = 3). Graft survival time was reduced in patients with moderate or high CMV levels in the graft soon after transplantation compared with that in patients with no or low CMV levels in the graft. No significant difference was observed in serum creatinine obtained at the time of early biopsies. Conclusions: We provide evidence that intragraft CMV protein expression is associated with end-stage chronic renal allograft dysfunction, that intragraft CMV levels increase as graft function deteriorates, and that CMV protein expression in the grafts soon after transplant is associated with reduced graft survival. Thus, CMV may have a pathological role in chronic renal allograft dysfunction. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
653 | a Pathology | |
653 | a Patologi | |
700 | 1 | a Rahbar, Afsaru Karolinska Institutet4 aut |
700 | 1 | a Yaiw, Koon-Chuu Karolinska Institutet4 aut |
700 | 1 | a Naghibi, Mansouru Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut |
700 | 1 | a Religa, Piotru Karolinska Institutet4 aut |
700 | 1 | a Fellström, Bengtu Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)bengfell |
700 | 1 | a Larsson, Eriku Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)eriklars |
700 | 1 | a Söderberg-Nauclér, Ceciliau Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för immunologi, genetik och patologi4 org |
773 | 0 | t Clinical Infectious Diseasesd : Oxford University Press (OUP)g 53:10, s. 969-976q 53:10<969-976x 1058-4838x 1537-6591 |
856 | 4 | u https://academic.oup.com/cid/article-pdf/53/10/969/952168/cir619.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-159724 |
856 | 4 8 | u https://doi.org/10.1093/cid/cir619 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:123439016 |
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