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MR spectroscopy of ...
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Weis, JanUppsala universitet,Enheten för radiologi
(författare)
MR spectroscopy of the human prostate using surface coil at 3 T : Metabolite ratios, age-dependent effects, and diagnostic possibilities
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2011-09-23
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Wiley,2011
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-160997
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160997URI
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https://doi.org/10.1002/jmri.22746DOI
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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PURPOSE: To measure prostate spectra of healthy volunteers using a surface coil, to demonstrate age-dependent effects, and to investigate diagnostic possibilities for prostate cancer detection. MATERIALS AND METHODS: Single-voxel and 2D magnetic resonance spectroscopic imaging (MRSI) spectra of 51 healthy volunteers with biopsy-proven prostate carcinoma of 20 patients for comparison were measured and processed using the LCModel. The mean normalized spectra and mean metabolite-to-citrate intensity ratios were computed. RESULTS: Metabolite-to-citrate ratios of healthy volunteers were lower in the older group (>51 years) than in the younger group (<45 years). The peripheral zone (PZ) revealed a lower metabolite-to-citrate intensity ratio than the central gland (CG). Age-related differences in metabolite-to-citrate ratio were insignificant in the voxels with predominantly CG tissue, whereas significant differences were found in the PZ. Sensitivity in detecting prostate cancer by single-voxel spectroscopy (SVS) and 2D MRSI was 75% and 80%, respectively. CONCLUSION: SVS and 2D MRSI of the prostate at 3 T, using a surface coil, are useful in situations when insertion of the endorectal coil into the rectum is difficult or impossible. Our findings of age-dependent effects may be of importance for the analysis of patient spectra.
Ämnesord och genrebeteckningar
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single-voxel spectroscopy
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spectroscopic imaging
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prostate cancer
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3 Tesla
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LCModel
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surface coil
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jorulf, HåkanUppsala universitet,Enheten för radiologi(Swepub:uu)hajor451
(författare)
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Bergman, AntoninaUppsala universitet,Enheten för radiologi(Swepub:uu)abe03125
(författare)
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Ortiz-Nieto, FranciscoUppsala universitet,Enheten för radiologi(Swepub:uu)fraor613
(författare)
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Häggman, MichaelUppsala universitet,Urologkirurgi(Swepub:uu)michhagg
(författare)
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Ahlström, HåkanUppsala universitet,Enheten för radiologi(Swepub:uu)hakanahl
(författare)
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Uppsala universitetEnheten för radiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Magnetic Resonance Imaging: Wiley34:6, s. 1277-12841053-18071522-2586
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