Sökning: onr:"swepub:oai:DiVA.org:uu-161334" >
The severity of tra...
The severity of trauma determines the immune response to PF4/heparin and the frequency of heparin-induced thrombocytopenia.
-
- Lubenow, Norbert (författare)
- Department of Transfusion Medicine, Greifswald University, Germany
-
Hinz, Peter (författare)
-
Thomaschewski, Simone (författare)
-
visa fler...
-
Lietz, Theresia (författare)
-
Vogler, Michael (författare)
-
Ladwig, Andrea (författare)
-
Jünger, Michael (författare)
-
Nauck, Matthias (författare)
-
Schellong, Sebastian (författare)
-
Wander, Kathrin (författare)
-
Engel, Georg (författare)
-
Ekkernkamp, Axel (författare)
-
Greinacher, Andreas (författare)
-
visa färre...
-
(creator_code:org_t)
- American Society of Hematology, 2010
- 2010
- Engelska.
-
Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 115:9, s. 1797-803
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Heparin can induce heparin-induced thrombocytopenia (HIT). The combined effect of type of surgery (major vs minor) and heparin on this prothrombotic immune reaction to platelet factor 4 (PF4)/heparin was analyzed. In a randomized, double-blind study, trauma patients receiving low-molecular-weight (LMWH) or unfractionated heparin (UFH) for thrombosis prophylaxis were assessed for PF4/heparin-antibody seroconversion, HIT, and thrombosis according to type of surgery. The risk for seroconversion was higher than major versus minor surgery odds ratio, 7.98 [95% confidence interval, 2.06-31.00], P = .003, controlled for potential confounders, as was the risk for HIT (2.2% [95% confidence interval, 0.3%-4.1%] vs 0.0%, P = .010). During LMWH compared with UFH thromboprophylaxis, HIT (1 of 298 vs 4 of 316; P = .370) and PF4/heparin seroconversion (1.7% vs 6.6%; P = .002) were less frequent, driven by differences in patients undergoing major surgery (incidence of HIT: LMWH 0.8% vs UFH 4.0%; P = .180; seroconversion rates: 4.0% vs 17.0%; P = .001). After minor surgery, no case of HIT occurred. The severity of trauma and the need for major surgery strongly influence the risk of an anti-PF4/heparin immune response, which is then increased by UFH. In major trauma certoparin may be safer than UFH because it induces HIT-antibody seroconversion, and the corresponding risk of HIT, less frequently.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Blood
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Lubenow, Norbert
-
Hinz, Peter
-
Thomaschewski, S ...
-
Lietz, Theresia
-
Vogler, Michael
-
Ladwig, Andrea
-
visa fler...
-
Jünger, Michael
-
Nauck, Matthias
-
Schellong, Sebas ...
-
Wander, Kathrin
-
Engel, Georg
-
Ekkernkamp, Axel
-
Greinacher, Andr ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Artiklar i publikationen
-
Blood
- Av lärosätet
-
Uppsala universitet