Sökning: onr:"swepub:oai:DiVA.org:uu-167651" >
Salivary cortisol l...
Salivary cortisol levels and allergy in children : The ALADDIN birth cohort
-
- Stenius, Fredrik (författare)
- Karolinska Institutet
-
- Borres, Magnus P., 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
-
- Bottai, Matteo (författare)
- Karolinska Institutet
-
visa fler...
-
- Lilja, Gunnar (författare)
- Karolinska Institutet
-
- Lindblad, Frank (författare)
- Stockholms universitet,Uppsala universitet,Barn- och ungdomspsykiatri,Stressforskningsinstitutet
-
- Pershagen, Goran (författare)
- Karolinska Institutet
-
- Scheynius, Annika (författare)
- Karolinska Institutet
-
Swartz, Jackie (författare)
-
- Theorell, Töres (författare)
- Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet,Enheten för epidemiologi
-
- Alm, Johan (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- Engelska.
-
Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 128:6, s. 1335-1339
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://gup.ub.gu.se...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Pre- and postnatal stress have been related to allergy in children, but evidence from prospective studies is limited. Several environmental factors can influence the salivary cortisol level, which is used as a measure of activity of the hypothalamic-pituitary-adrenal axis.Objective: The aim of this study was to assess the association between salivary cortisol levels at 6 months of age and allergic manifestations during the first 2 years of life.Methods: Salivary samples for the analysis of cortisol level were collected at 6 months of age on 3 occasions during 1 day from 203 children. Blood samples were collected at 6, 12, and 24 months of age for analyses of specific IgE. Information on allergy-related symptoms was obtained by repeated examinations of the children. Generalized estimating equation statistics were used to calculate the overall risk for outcome measures.Results: The adjusted odds ratio for the relationship between morning cortisol level and IgE sensitization was 1.60 (95% CI, 1.22-2.10, P = .001) and for eczema it was 1.28 (95% CI, 1.03-1.59, P = .026). The odds ratio for afternoon cortisol level in relation to sensitization and eczema was 1.56 (95% CI, 1.26-1.94, P < .001) and 1.33 (95% CI, 1.12-1.58, P = .001), respectively, and for evening cortisol level it was 1.49 (95% CI, 1.22-1.83, P < .001) and 1.37 (95% CI, 1.18-1.59, P < .001). Salivary cortisol level in the evening was associated with food allergy.Conclusion: The association between salivary cortisol levels in infancy and allergic sensitization and allergic symptoms suggests a role of an altered hypothalamic-pituitary-adrenal axis in the etiological process of allergies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Allergy
- sensitization
- salivary cortisol
- children
- stress
- allergy
- sensitization
- salivary cortisol
- children
- stress
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Stenius, Fredrik
-
Borres, Magnus P ...
-
Bottai, Matteo
-
Lilja, Gunnar
-
Lindblad, Frank
-
Pershagen, Goran
-
visa fler...
-
Scheynius, Annik ...
-
Swartz, Jackie
-
Theorell, Töres
-
Alm, Johan
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Lungmedicin och ...
- Artiklar i publikationen
-
Journal of Aller ...
- Av lärosätet
-
Uppsala universitet
-
Stockholms universitet
-
Karolinska Institutet
-
Göteborgs universitet