Sökning: onr:"swepub:oai:DiVA.org:uu-170767" >
Differential effect...
Differential effect of PYY1-36 and PYY3-36 on gastric emptying in man
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
-
Elsevier BV,2009
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-170767
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-170767URI
-
https://doi.org/10.1016/j.regpep.2009.07.013DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:119589251URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Peptide tyrosine-tyrosine (PYY) is a prandially controlled hormone in endocrine ileal and colonic mucosa cells. In plasma, PYY appears as full-length PYY1-36 and truncated PYY3-36. Both have different pharmacological profile, and PYY3-36 seems to inhibit food intake. We aimed at investigating the effect of intravenously administered PYY1-36 and PYY3-36 on gastric emptying and short-term metabolic control. Eight healthy adults were studied in single-blinded, randomized design. At separate occasions, intravenous infusion of saline, PYY1-36 or PYY3-36 (0.8 pmol kg− 1 min− 1) and a radio-labelled omelette were given. Gastric emptying (scintigraphy), appetite ratings (VAS), and plasma concentrations of insulin, glucose, GLP-1 and PYY were measured. PYY3-36 and PYY1-36 both inhibited gastric emptying, PYY3-36 most effectively. Half-emptying time was prolonged from 63.1 ± 5.2 (saline) to 87.0 ± 11.5 min (PYY3-36), whereas retention at 120 min was 2.5 ± 1.4% for saline, 10.7 ± 4.4 for PYY1-36 and 15.8 ± 4.4 for PYY3-36. Neither form influenced glucose or GLP-1 concentrations, but both decreased the postprandial rise in insulin. PYY3-36 induced nausea (VAS increase 47.5 ± 22.6 mm) and decreased prospective consumption (VAS change 39.5 ± 7.7 mm). In conclusion, PYY3-36's reducing effect upon food intake might be mediated by a decreased gastric emptying rate.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Grybäck, PKarolinska Institutet
(författare)
-
Holst, J JKarolinska Institutet
(författare)
-
Hilsted, L
(författare)
-
Hellström, Per M.,1954-
(författare)
-
Jacobsson, H
(författare)
-
Schmidt, P TKarolinska Institutet
(författare)
-
Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Regulatory Peptides: Elsevier BV158:1-3, s. 57-620167-01151873-1686
Internetlänk
Hitta via bibliotek
Till lärosätets databas