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Dietary Cadmium Exp...
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Julin, BettinaKarolinska Institutet
(författare)
Dietary Cadmium Exposure and Risk of Postmenopausal Breast Cancer : A Population-Based Prospective Cohort Study
- Artikel/kapitelEngelska2012
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LIBRIS-ID:oai:DiVA.org:uu-172826
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-172826URI
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https://doi.org/10.1158/0008-5472.CAN-11-0735DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:124263272URI
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Språk:engelska
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Sammanfattning på:engelska
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The ubiquitous food contaminant cadmium has features of an estrogen mimetic that may promote the development of estrogen-dependent malignancies, such as breast cancer. However, no prospective studies of cadmium exposure and breast cancer risk have been reported. , We examined the association between dietary cadmium exposure (at baseline, 1987) and the risk of overall and estrogen receptor (ER)-defined (ER+ or ER-) breast cancer within a population-based prospective cohort of 55,987 postmenopausal women. During an average of 12.2 years of follow-up, 2,112 incident cases of invasive breast cancer were ascertained (1,626 ER+ and 290 ER-). After adjusting for confounders, including consumption of whole grains and vegetables (which account for 40% of the dietary exposure, but also contain putative anticarcinogenic phytochemicals), dietary cadmium intake was positively associated with overall breast cancer tumors, comparing the highest tertile with the lowest [rate ratio (RR), 1.21; 95% confidence interval (CI), 1.07-1.36; P-trend = 0.02]. Among lean and normal weight women, statistically significant associations were observed for all tumors (RR, 1.27; 95% CI, 1.07-1.50) and for ER+ tumors (RR, 125; 95% CI, 1.03-1.52) and similar, but not statistically significant associations were found for ER- tumors (RR, 1.22; 95% CI, 0.76-1.93). The risk of breast cancer increased with increasing cadmium exposure similarly within each textile of whole grain/vegetable consumption and decreased with increasing consumption of whole grain/vegetables within each tertile of cadmium exposure (P-interaction = 0.73). Overall, these results suggest a role for dietary cadmium in postmenopausal breast cancer development.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Wolk, AlicjaKarolinska Institutet
(författare)
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Bergkvist, LeifUppsala universitet,Centrum för klinisk forskning, Västerås(Swepub:uu)leber451
(författare)
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Bottai, MatteoKarolinska Institutet
(författare)
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Akesson, AgnetaKarolinska Institutet
(författare)
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Karolinska InstitutetCentrum för klinisk forskning, Västerås
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cancer Research72:6, s. 1459-14660008-54721538-7445
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