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Periprocedural Blee...
Periprocedural Bleeding and Thromboembolic Events With Dabigatran Compared With Warfarin Results From the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) Randomized Trial
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Healey, Jeff S. (författare)
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Eikelboom, John (författare)
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Douketis, James (författare)
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- Wallentin, Lars, 1943- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),kardiologi
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- Oldgren, Jonas (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),kardiologi
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Yang, Sean (författare)
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Themeles, Ellison (författare)
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Heidbuchle, Hein (författare)
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Avezum, Alvaro (författare)
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Reilly, Paul (författare)
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Connolly, Stuart J. (författare)
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Yusuf, Salim (författare)
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Ezekowitz, Michael (författare)
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(creator_code:org_t)
- 2012
- 2012
- Engelska.
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Ingår i: Circulation. - 0009-7322 .- 1524-4539. ; 126:3, s. 343-348
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background-Dabigatran reduces ischemic stroke in comparison with warfarin; however, given the lack of antidote, there is concern that it might increase bleeding when surgery or invasive procedures are required.Methods and Results-The current analysis was undertaken to compare the periprocedural bleeding risk of patients in the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial treated with dabigatran and warfarin. Bleeding rates were evaluated from 7 days before until 30 days after invasive procedures, considering only the first procedure for each patient. A total of 4591 patients underwent at least 1 invasive procedure: 24.7% of patients received dabigatran 110 mg, 25.4% received dabigatran 150 mg, and 25.9% received warfarin, P=0.34. Procedures included: pacemaker/defibrillator insertion (10.3%), dental procedures (10.0%), diagnostic procedures (10.0%), cataract removal (9.3%), colonoscopy (8.6%), and joint replacement (6.2%). Among patients assigned to either dabigatran dose, the last dose of study drug was given 49 (35-85) hours before the procedure on comparison with 114 (87-144) hours in patients receiving warfarin, P<0.001. There was no significant difference in the rates of periprocedural major bleeding between patients receiving dabigatran 110 mg (3.8%) or dabigatran 150 mg (5.1%) or warfarin (4.6%); dabigatran 110 mg versus warfarin: relative risk, 0.83; 95% CI, 0.59 to 1.17; P=0.28; dabigatran 150 mg versus warfarin: relative risk, 1.09; 95% CI, 0.80 to 1.49; P=0.58. Among patients having urgent surgery, major bleeding occurred in 17.8% with dabigatran 110 mg, 17.7% with dabigatran 150 mg, and 21.6% with warfarin: dabigatran 110 mg; relative risk, 0.82; 95% CI, 0.48 to 1.41; P=0.47; dabigatran 150 mg: relative risk, 0.82; 95% CI, 0.50 to 1.35; P=0.44.Conclusions-Dabigatran and warfarin were associated with similar rates of periprocedural bleeding, including patients having urgent surgery. Dabigatran facilitated a shorter interruption of oral anticoagulation.
Nyckelord
- anticoagulants
- atrial fibrillation
- stroke prevention
- surgery
- perioperative
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Healey, Jeff S.
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Eikelboom, John
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Douketis, James
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Wallentin, Lars, ...
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Oldgren, Jonas
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Yang, Sean
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visa fler...
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Themeles, Elliso ...
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Heidbuchle, Hein
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Avezum, Alvaro
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Reilly, Paul
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Connolly, Stuart ...
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Yusuf, Salim
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Ezekowitz, Micha ...
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visa färre...
- Artiklar i publikationen
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Circulation
- Av lärosätet
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Uppsala universitet