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Role of neutrophils...
Role of neutrophils in hemorrhagic shock-induced gastric mucosal injury in the rat
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Smith, S M (författare)
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- Holm-Rutili, Lena (författare)
- Uppsala universitet,Integrativ Fysiologi
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Perry, M A (författare)
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visa fler...
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- Grisham, M B (författare)
- Uppsala universitet,Integrativ Fysiologi
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Arfors, K E (författare)
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Granger, D N (författare)
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Kvietys, P R (författare)
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visa färre...
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(creator_code:org_t)
- 1987
- 1987
- Engelska.
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Ingår i: Gastroenterology. - 0016-5085 .- 1528-0012. ; 93:3, s. 466-471
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Gastric mucosal clearance of 51Cr-labeled red blood cells (51Cr-RBC) was measured in rats during a 30-min control period, a 30-min ischemic period (hemorrhage to 27 mmHg arterial pressure), and a 60-min reperfusion period (reinfusion of shed blood). In untreated (control) rats, a dramatic rise in the leakage of 51Cr-labeled red blood cells into the gastric lumen was observed during the reperfusion period. Treatment with neutrophil antiserum attenuated 51Cr-labeled red blood cell flux into the gastric lumen. Using the radioactive microsphere technique, neutrophil-depleted animals were shown to have higher blood flows in the ischemic period than the untreated rats. Bleeding of untreated rats to a mean arterial pressure of 40 mmHg resulted in blood flows that were not different from those in antiserum-treated rats bled to 27 mmHg and leakage of 51Cr-labeled red blood cells similar to that measured in antiserum-treated rats. The results of this study indicate that neutrophils play an important role in hemorrhagic shock-induced gastric bleeding.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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