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Role of neutrophils...
Role of neutrophils in hemorrhagic shock-induced gastric mucosal injury in the rat
- Artikel/kapitelEngelska1987
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LIBRIS-ID:oai:DiVA.org:uu-188279
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-188279URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Gastric mucosal clearance of 51Cr-labeled red blood cells (51Cr-RBC) was measured in rats during a 30-min control period, a 30-min ischemic period (hemorrhage to 27 mmHg arterial pressure), and a 60-min reperfusion period (reinfusion of shed blood). In untreated (control) rats, a dramatic rise in the leakage of 51Cr-labeled red blood cells into the gastric lumen was observed during the reperfusion period. Treatment with neutrophil antiserum attenuated 51Cr-labeled red blood cell flux into the gastric lumen. Using the radioactive microsphere technique, neutrophil-depleted animals were shown to have higher blood flows in the ischemic period than the untreated rats. Bleeding of untreated rats to a mean arterial pressure of 40 mmHg resulted in blood flows that were not different from those in antiserum-treated rats bled to 27 mmHg and leakage of 51Cr-labeled red blood cells similar to that measured in antiserum-treated rats. The results of this study indicate that neutrophils play an important role in hemorrhagic shock-induced gastric bleeding.
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Holm-Rutili, LenaUppsala universitet,Integrativ Fysiologi(Swepub:uu)pho23887
(författare)
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Perry, M A
(författare)
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Grisham, M BUppsala universitet,Integrativ Fysiologi
(författare)
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Arfors, K E
(författare)
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Granger, D N
(författare)
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Kvietys, P R
(författare)
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Uppsala universitetIntegrativ Fysiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Gastroenterology93:3, s. 466-4710016-50851528-0012
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