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Gadolinium-153 as a...
Gadolinium-153 as a brachytherapy isotope
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- Enger, Shirin A. (författare)
- Uppsala universitet,Enheten för onkologi
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Fisher, Darrell R. (författare)
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Flynn, Ryan T. (författare)
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(creator_code:org_t)
- 2013-01-23
- 2013
- Engelska.
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Ingår i: Physics in Medicine and Biology. - : IOP Publishing. - 0031-9155 .- 1361-6560. ; 58:4, s. 957-964
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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Abstract
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- The purpose of this work was to present the fundamental dosimetric characteristics of a hypothetical Gd-153 brachytherapy source using the AAPM TG-43U1 dose-calculation formalism. Gadolinium-153 is an intermediate-energy isotope that emits 40-100 keV photons with a half-life of 242 days. The rationale for considering Gd-153 as a brachytherapy source is for its potential of patient specific shielding and to enable reduced personnel shielding requirements relative to Ir-192, and as an isotope for interstitial rotating shield brachytherapy (I-RSBT). A hypothetical Gd-153 brachytherapy source with an active core of 0.84 mm diameter, 10 mm length and specific activity of 5.55 TBq of Gd-153 per gram of Gd was simulated with Geant4. The encapsulation material was stainless steel with a thickness of 0.08 mm. The radial dose function, anisotropy function and photon spectrum in water were calculated for the Gd-153 source. The simulated Gd-153 source had an activity of 242 GBq and a dose rate in water 1 cm off axis of 13.12 Gy h(-1), indicating that it would be suitable as a low-dose-rate or pulsed-dose-rate brachytherapy source. The beta particles emitted have low enough energies to be absorbed in the source encapsulation. Gadolinium-153 has an increasing radial dose function due to multiple scatter of low-energy photons. Scattered photon dose takes over with distance from the source and contributes to the majority of the absorbed dose. The anisotropy function of the Gd-153 source decreases at low polar angles, as a result of the long active core. The source is less anisotropic at polar angles away from the longitudinal axes. The anisotropy function increases with increasing distance. The Gd-153 source considered would be suitable as an intermediate-energy low-dose-rate or pulsed-dose-rate brachytherapy source. The source could provide a means for I-RSBT delivery and enable brachytherapy treatments with patient specific shielding and reduced personnel shielding requirements relative to Ir-192.
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