Sökning: onr:"swepub:oai:DiVA.org:uu-196970" > Novel Loci for Adip...
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000 | 07488naa a2201621 4500 | |
001 | oai:DiVA.org:uu-196970 | |
003 | SwePub | |
008 | 130315s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1969702 URI |
024 | 7 | a https://doi.org/10.1371/journal.pgen.10026072 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Dastani, Zari4 aut |
245 | 1 0 | a Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits :b A Multi-Ethnic Meta-Analysis of 45,891 Individuals |
264 | c 2012-03-29 | |
264 | 1 | b Public Library of Science (PLoS),c 2012 |
338 | a print2 rdacarrier | |
500 | a Group Author(s): DIAGRAM Consortium ; MAGIC Consortium ; GLGC Investigators ; MuTHER ConsortiumAnn-Christine Syvänen (Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper) is a member of the MAGIC ConsortiumFor complete list of Consortia Authors see http://dx.doi.org/10.1371/journal.pgen.1002607 | |
520 | a Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P=4.5 x 10(-8)-1.2 x 10(-43)). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3 x 10(-4)). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p=4.3 x 10(-3), n = 22,044), increased triglycerides (p=2.6 x 10(-14), n = 93,440), increased waist-to-hip ratio (p=1.8 x 10(-5), n = 77,167), increased glucose two hours post oral glucose tolerance testing (p=4.4 x 10(-3), n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL-cholesterol concentrations (p=4.5x10(-13), n = 96,748) and decreased BMI (p= 1.4 x 10(-14), n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance. | |
700 | 1 | a Hivert, Marie-France4 aut |
700 | 1 | a Timpson, Nicholas4 aut |
700 | 1 | a Perry, John R. B.4 aut |
700 | 1 | a Yuan, Xin4 aut |
700 | 1 | a Scott, Robert A.4 aut |
700 | 1 | a Henneman, Peter4 aut |
700 | 1 | a Heid, Iris M.4 aut |
700 | 1 | a Kizer, Jorge R.4 aut |
700 | 1 | a Lyytikainen, Leo-Pekka4 aut |
700 | 1 | a Fuchsberger, Christian4 aut |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a Morris, Andrew P.4 aut |
700 | 1 | a Small, Kerrin4 aut |
700 | 1 | a Isaacs, Aaron4 aut |
700 | 1 | a Beekman, Marian4 aut |
700 | 1 | a Coassin, Stefan4 aut |
700 | 1 | a Lohman, Kurt4 aut |
700 | 1 | a Qi, Lu4 aut |
700 | 1 | a Kanoni, Stavroula4 aut |
700 | 1 | a Pankow, James S.4 aut |
700 | 1 | a Uh, Hae-Won4 aut |
700 | 1 | a Wu, Ying4 aut |
700 | 1 | a Bidulescu, Aurelian4 aut |
700 | 1 | a Rasmussen-Torvik, Laura J.4 aut |
700 | 1 | a Greenwood, Celia M. T.4 aut |
700 | 1 | a Ladouceur, Martin4 aut |
700 | 1 | a Grimsby, Jonna4 aut |
700 | 1 | a Manning, Alisa K.4 aut |
700 | 1 | a Liu, Ching-Ti4 aut |
700 | 1 | a Kooner, Jaspal4 aut |
700 | 1 | a Mooser, Vincent E.4 aut |
700 | 1 | a Vollenweider, Peter4 aut |
700 | 1 | a Kapur, Karen A.4 aut |
700 | 1 | a Chambers, John4 aut |
700 | 1 | a Wareham, Nicholas J.4 aut |
700 | 1 | a Langenberg, Claudia4 aut |
700 | 1 | a Frants, Rune4 aut |
700 | 1 | a Willems-vanDijk, Ko4 aut |
700 | 1 | a Oostra, Ben A.4 aut |
700 | 1 | a Willems, Sara M.4 aut |
700 | 1 | a Lamina, Claudia4 aut |
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700 | 1 | a Tracy, Russell P.4 aut |
700 | 1 | a Brody, Jennifer4 aut |
700 | 1 | a Chen, Ida4 aut |
700 | 1 | a Viikari, Jorma4 aut |
700 | 1 | a Kahonen, Mika4 aut |
700 | 1 | a Pramstaller, Peter P.4 aut |
700 | 1 | a Evans, David M.4 aut |
700 | 1 | a St Pourcain, Beate4 aut |
700 | 1 | a Sattar, Naveed4 aut |
700 | 1 | a Wood, Andrew R.4 aut |
700 | 1 | a Bandinelli, Stefania4 aut |
700 | 1 | a Carlson, Olga D.4 aut |
700 | 1 | a Egan, Josephine M.4 aut |
700 | 1 | a Bohringer, Stefan4 aut |
700 | 1 | a van Heemst, Diana4 aut |
700 | 1 | a Kedenko, Lyudmyla4 aut |
700 | 1 | a Kristiansson, Kati4 aut |
700 | 1 | a Nuotio, Marja-Liisa4 aut |
700 | 1 | a Loo, Britt-Marie4 aut |
700 | 1 | a Harris, Tamara4 aut |
700 | 1 | a Garcia, Melissa4 aut |
700 | 1 | a Kanaya, Alka4 aut |
700 | 1 | a Haun, Margot4 aut |
700 | 1 | a Klopp, Norman4 aut |
700 | 1 | a Wichmann, H. -Erich4 aut |
700 | 1 | a Deloukas, Panos4 aut |
700 | 1 | a Katsareli, Efi4 aut |
700 | 1 | a Couper, David J.4 aut |
700 | 1 | a Duncan, Bruce B.4 aut |
700 | 1 | a Kloppenburg, Margreet4 aut |
700 | 1 | a Adair, Linda S.4 aut |
700 | 1 | a Borja, Judith B.4 aut |
700 | 1 | a Wilson, James G.4 aut |
700 | 1 | a Musani, Solomon4 aut |
700 | 1 | a Guo, Xiuqing4 aut |
700 | 1 | a Johnson, Toby4 aut |
700 | 1 | a Semple, Robert4 aut |
700 | 1 | a Teslovich, Tanya M.4 aut |
700 | 1 | a Allison, Matthew A.4 aut |
700 | 1 | a Redline, Susan4 aut |
700 | 1 | a Buxbaum, Sarah G.4 aut |
700 | 1 | a Mohlke, Karen L.4 aut |
700 | 1 | a Meulenbelt, Ingrid4 aut |
700 | 1 | a Ballantyne, Christie M.4 aut |
700 | 1 | a Dedoussis, George V.4 aut |
700 | 1 | a Hu, Frank B.4 aut |
700 | 1 | a Liu, Yongmei4 aut |
700 | 1 | a Paulweber, Bernhard4 aut |
700 | 1 | a Spector, Timothy D.4 aut |
700 | 1 | a Slagboom, P. Eline4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Jula, Antti4 aut |
700 | 1 | a Perola, Markus4 aut |
700 | 1 | a Raitakari, Olli4 aut |
700 | 1 | a Florez, Jose C.4 aut |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Eriksson, Johan G.4 aut |
700 | 1 | a Frayling, Timothy M.4 aut |
700 | 1 | a Hicks, Andrew A.4 aut |
700 | 1 | a Lehtimaki, Terho4 aut |
700 | 1 | a Smith, George Davey4 aut |
700 | 1 | a Siscovick, David S.4 aut |
700 | 1 | a Kronenberg, Florian4 aut |
700 | 1 | a van Duijn, Cornelia4 aut |
700 | 1 | a Loos, Ruth J. F.4 aut |
700 | 1 | a Waterworth, Dawn M.4 aut |
700 | 1 | a Meigs, James B.4 aut |
700 | 1 | a Dupuis, Josee4 aut |
700 | 1 | a Richards, J. Brent4 aut |
773 | 0 | t PLOS Geneticsd : Public Library of Science (PLoS)g 8:3, s. e1002607-q 8:3<e1002607-x 1553-7390x 1553-7404 |
856 | 4 | u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002607&type=printable |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-196970 |
856 | 4 8 | u https://doi.org/10.1371/journal.pgen.1002607 |
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