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The frequency of an...
The frequency of an IL-18-associated haplotype in Africans
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Thompson, Simon R. (författare)
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Humphries, Steve E. (författare)
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- Thomas, Mark G. (författare)
- Uppsala universitet,Evolutionsbiologi
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Ekong, Rosemary (författare)
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Tarekegn, Ayele (författare)
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Bekele, Endeshaw (författare)
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Creemer, Olivia (författare)
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Bradman, Neil (författare)
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Veeramah, Krishna R. (författare)
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(creator_code:org_t)
- 2012-08-29
- 2013
- Engelska.
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Ingår i: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 21:4, s. 465-468
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Variation within the gene for the proinflammatory cytokine interleukin (IL)-18 has been associated with inter-individual differences in levels of free protein and disease risk. We investigated the frequency of function-associated IL18 gene haplotypes in an extensive sample (n=2357) of African populations from across the continent. A previously identified five tagging SNP (single-nucleotide polymorphism) haplotype (here designated hGTATA), known to be associated with lower levels of IL-18, was observed at a frequency of 27% in a British population of recent European ancestry, but was found at low frequency (<8%) or completely absent in African populations. Potentially protective variants may, as a consequence, be found at low frequency in African individuals and may confer a difference in disease risk.
Nyckelord
- IL-18
- atherosclerosis
- genetic diversity
- Africa
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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