Ovarian Steroid Hormones, Emotion Processing and Mood

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Gingnell, Malin,1982-Uppsala universitet,Obstetrik & gynekologi (författare)

Ovarian Steroid Hormones, Emotion Processing and Mood

BokEngelska2013

Förlag, utgivningsår, omfång ...

Uppsala :Acta Universitatis Upsaliensis,2013
77 s.
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:uu-199791
ISBN:9789155486938
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-199791URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:vet swepub-contenttype
Ämneskategori:dok swepub-publicationtype

Serie

Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine,1651-6206 ;912

Anmärkningar

It is known that some psychiatric disorders may deteriorate in relation to the menstrual cycle. However, in some conditions, such as premenstrual dysphoric disorder (PMDD), symptomatology is triggered mainly by the variations in ovarian steroid hormones. Although symptoms induced by fluctuations in ovarian steroids often are affective, little is known about how emotion processing in women is influenced by variations, or actual levels, of ovarian steroid hormones.The general aim of this thesis was to evaluate menstrual cycle effects on reactivity in emotion generating and controlling areas in the corticolimbic system to emotional stimulation and anticipation, in healthy controls and women with PMDD. A second aim was to evaluate corticolimbic reactivity during long-term administration of exogenous ovarian steroids.In study I, III and IV effects of the menstrual cycle on emotional reactivity in women with PMDD was studied. In study I, women with PMDD in displayed higher amygdala reactivity than healthy controls to emotional faces, not in the luteal phase as was hypothesised, but in the follicular phase. No difference between menstrual cycle phases was obtained in women with PMDD, while healthy controls had an increased reactivity in the luteal phase. The results of study I was further elaborated in study III, where women with PMDD were observed to have an increased anticipatory reactivity to negative emotional stimuli. However, no differences in amygdala reactivity to emotional stimuli were obtained across the menstrual cycle. Finally, in study IV the hypothesis that amygdala reactivity increase in the luteal phase in women with PMDD is linked to social stimuli rather than generally arousing stimuli was suggested, tested and supported.In study II, re-exposure to COC induced mood symptoms de novo in women with a previous history of COC-induced adverse mood. Women treated with COC reported increased levels of mood symptoms both as compared to before treatment, and as compared to the placebo group. There was a relatively strong correlation between depressive scores before and during treatment. The effects of repeated COC administration on subjective measures and brain function were however dissociated with increased aversive experiences accompanied by reduced reactivity in the insular cortex.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
SAMHÄLLSVETENSKAP Psykologi Psykologi hsv//swe
SOCIAL SCIENCES Psychology Psychology hsv//eng
premenstrual dysphoric disorder
menstrual cycle
combined oral contraceptives
estrogen
estradiol
progesterone
ethinyl-estradiol
levonorgestrel
randomized clinical trial
placebo
fMRI
amygdala
ACC
insula
dlPFC
mPFC
IFG
MFG
Medicinsk vetenskap
Medical Science
Obstetrik och gynekologi
Obstetrics and Gynaecology

Biuppslag (personer, institutioner, konferenser, titlar ...)

Sundström-Poromaa, IngerUppsala universitet,Obstetrik & gynekologi (preses)
Fredrikson, MatsUppsala universitet,Institutionen för psykologi (preses)
Wikström, JohanUppsala universitet,Enheten för radiologi (preses)
Cahill, Larry,ProfessorUniversity of California, Irvine (opponent)
Uppsala universitetObstetrik & gynekologi (creator_code:org_t)

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Av författaren/redakt...: Gingnell, Malin, ...; Sundström-Poroma ...; Fredrikson, Mats; Wikström, Johan; Cahill, Larry, P ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reproduktionsmed ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Radiologi och bi ...

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