onr:"swepub:oai:DiVA.org:uu-208791"
Sökning: onr:"swepub:oai:DiVA.org:uu-208791" > Neurospora tetraspe...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Corcoran, PádraicUppsala universitet,Evolutionsbiologi (författare)
Neurospora tetrasperma from Natural Populations : Toward the Population Genomics of a Model Fungus
- BokEngelska2013
Förlag, utgivningsår, omfång ...
- Uppsala :Acta Universitatis Upsaliensis,2013
- 52 s.
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-208791
- ISBN:9789155487713
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-208791URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Serie
- Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology,1651-6214 ;1084
Anmärkningar
- The study of DNA sequence variation is a powerful approach to study genome evolution, and to reconstruct evolutionary histories of species. In this thesis, I have studied genetic variation in the fungus Neurospora tetrasperma and other closely related Neurospora species. I have focused on N. tetrasperma in my research because it has large regions of suppressed recombination on its mating-type chromosomes, had undergone a recent change in reproductive mode and is composed of multiple reproductively isolated lineages. Using DNA sequence data from a large sample set representing multiple species of Neurospora I estimated that N. tetrasperma evolved ~1 million years ago and that it is composed of at least 10 lineages. My analysis of the type of asexual spores produced using newly described N. tetrasperma populations in Britain revealed that lineages differ considerably in life history characteristics that may have consequences for their evolution. A comparative genomic analysis using three genomes of N. tetrasperma and the genome of N. crassa revealed that the mat a chromosomes in the lineages examine have been introgressed from other Neurospora species and that this introgression has reduced levels of molecular degeneration on the mating-type chromosomes. Finally, I generated a population genomic dataset composed of 92 N. tetrasperma genomes and two genomes of other Neurospora species. Analysis of these genomes revealed that all strains of N. tetrasperma have large regions of suppressed recombination on their mating-type chromosomes ranging from 69-84% of the chromosome and that the extent of divergence between mating-type chromosomes within lineages varies greatly (from 1.3 to 3.2%). I concluded that the source of this great divergence mating-type chromosome is large-scale introgression from other Neurospora species, and that these introgressed tracts have become fixed within N. tetrasperma lineages. I also discovered that genes within non-recombining introgressed regions of the mating-type chromosome have severely reduced levels of genetic variation as compared to the autosomes, and exhibit signatures of reduced molecular degeneration. My analysis of variation in coding regions revealed that positive selection on the introgressed regions has resulted in the removal of deleterious mutations and is responsible for the reductions in molecular degeneration observed.
Ämnesord och genrebeteckningar
- NATURVETENSKAP Biologi Evolutionsbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Evolutionary Biology hsv//eng
- NATURVETENSKAP Biologi Genetik hsv//swe
- NATURAL SCIENCES Biological Sciences Genetics hsv//eng
- Neurospora
- poulation genetics
- genomes
- introgression
- Evolutionary Genetics
- Evolutionär genetik
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Johannesson, HannaUppsala universitet,Evolutionsbiologi (preses)
- Glemin, SylvainMontepellier University (opponent)
- Uppsala universitetEvolutionsbiologi (creator_code:org_t)
Internetlänk
Hitta via bibliotek
- Neurospora tetrasperma from Natural Populations Toward the Population Genomics o... (Sök publikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Corcoran, Pádrai ...
- Johannesson, Han ...
- Glemin, Sylvain
- Om ämnet
-
- NATURVETENSKAP
- NATURVETENSKAP
- och Biologi
- och Evolutionsbiolog ...
-
- NATURVETENSKAP
- NATURVETENSKAP
- och Biologi
- och Genetik
- Delar i serien
- Digital Comprehe ...
- Av lärosätet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
