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Risk of symptomatic...
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Johansson, K.Karolinska Institutet
(författare)
Risk of symptomatic gallstones and cholecystectomy after a very-low-calorie diet or low-calorie diet in a commercial weight loss program : 1-year matched cohort study
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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2013-05-22
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Nature Publishing Group,2014
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-221006
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-221006URI
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https://doi.org/10.1038/ijo.2013.83DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-4741URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:128347418URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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BACKGROUND: Concern exists regarding gallstones as an adverse event of very-low-calorie diets (VLCDs; <800 kcal per day). OBJECTIVE: To assess the risk of symptomatic gallstones requiring hospital care and/or cholecystectomy in a commercial weight loss program using VLCD or low-calorie diet (LCD). DESIGN: A 1-year matched cohort study of consecutively enrolled adults in a commercial weight loss program conducted at 28 Swedish centers between 2006 and 2009. A 3-month weight loss phase of VLCD (500 kcal per day) or LCD (1200-1500 kcal per day) was followed by a 9-month weight maintenance phase. Matching (1: 1) was performed by age, sex, body mass index, waist circumference and gallstone history (n = 3320: 3320). Gallstone and cholecystectomy data were retrieved from the Swedish National Patient Register. RESULTS: One-year weight loss was greater in the VLCD than in the LCD group (-11.1 versus -8.1 kg; adjusted difference, -2.8 kg, 95% CI -3.1 to -2.4; P<0.001). During 6361 person-years, 48 and 14 gallstones requiring hospital care occurred in the VLCD and LCD groups, respectively, (152 versus 44/10 000 person-years; hazard ratio, 3.4, 95% CI 1.8-6.3; P<0.001; number-needed-to-harm, 92, 95% CI 63-168; P<0.001). Of the 62 gallstone events, 38 (61%) resulted in cholecystectomy (29 versus 9; hazard ratio, 3.2, 95% CI 1.5-6.8; P = 0.003; number-needed-to-harm, 151, 95% CI 94-377; P<0.001). Adjusting for 3-month weight loss attenuated the hazard ratios, but the risk remained higher with VLCD than LCD for gallstones (2.5, 95% CI 1.3-5.1; P = 0.009) and became borderline for cholecystectomy (2.2, 95% CI 0.9-5.2; P = 0.08). CONCLUSION: The risk of symptomatic gallstones requiring hospitalization or cholecystectomy, albeit low, was 3-fold greater with VLCD than LCD during the 1-year commercial weight loss program.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sundström, J.Uppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)johasund
(författare)
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Marcus, C.Karolinska Institutet
(författare)
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Hemmingsson, ErikKarolinska institutet(Swepub:gih)erik.hemmingsson
(författare)
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Neovius, M.Karolinska Institutet
(författare)
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Karolinska InstitutetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Obesity: Nature Publishing Group38:2, s. 279-2840307-05651476-5497
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