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Determinants of car...
Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults - a KIMS database analysis.
- Artikel/kapitelEngelska2006
Förlag, utgivningsår, omfång ...
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Oxford University Press (OUP),2006
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-22162
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-22162URI
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https://doi.org/10.1530/eje.1.02179DOI
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Objective: The aim of the present study was to clarify the relationship between GH deficiency (GHD) andsome cardiovascular risk factors and to analyse the effect of GH replacement therapy in a large numberof patients over a prolonged period of time.Design: Data for analysis were retrieved from KIMS (Pfizer International Metabolic Database). Serumconcentrations of total cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein(LDL)-cholesterol and triglycerides were obtained from 2589 patients at baseline and from 1206patients after 1 and 2 years of GH replacement therapy. Body mass index (BMI), waist and hip, restingblood pressure and body composition were also measured.Results: At baseline, the unfavourable effects of GHD were most obvious in the lipid profiledemonstrating elevated mean total and LDL-cholesterol, in the increased waist circumference and theelevated BMI. The cholesterol concentration, BMI and body composition were significantly adverselyaffected by a number of factors, including age, sex and the use of anti-epileptic drugs. The therapeuticeffect of GH was essentially uniform across the whole population. GH replacement reduced significantlythe mean total and LDL-cholesterol, the waist circumference and the fat mass and was maintainedduring 2 years.Conclusions: This analysis of a large number of patients confirmed that GHD adults present with anincreased cardiovascular risk. The sustained improvement of the adverse lipid profile and bodycomposition suggests that GH replacement therapy may reduce the risk of cardiovascular disease andthe premature mortality seen in hypopituitary patients with untreated GHD.
Ämnesord och genrebeteckningar
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Adult
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Age Factors
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Age of Onset
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Aged
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Blood Pressure/physiology
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Body Composition/physiology
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Body Mass Index
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Cardiovascular Diseases/blood/*epidemiology/*etiology
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Cholesterol/blood
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Cholesterol; HDL/blood
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Cholesterol; LDL/blood
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Databases; Factual
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Female
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Growth Hormone/therapeutic use
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Hormone Replacement Therapy
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Human Growth Hormone/*deficiency
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Humans
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Hypopituitarism/*complications/drug therapy
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Insulin-Like Growth Factor I/metabolism
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Male
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Middle Aged
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Regression Analysis
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Risk Factors
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Sex Factors
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Triglycerides/blood
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Waist-Hip Ratio
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Feldt-Rasmussen, Ulla
(författare)
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Mattsson, Anders F
(författare)
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Monson, John P
(författare)
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Bengtsson, Bengt-Ake
(författare)
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Goth, M I
(författare)
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Wilton, Patrick
(författare)
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Koltowska-Häggström, MariaUppsala universitet,Institutionen för farmaci
(författare)
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Uppsala universitetInstitutionen för farmaci
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Endocrinology: Oxford University Press (OUP)155:1, s. 79-900804-46431479-683X
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