Sökning: onr:"swepub:oai:DiVA.org:uu-229388" >
Immunotherapy targe...
-
Lindström, VeronicaUppsala universitet,Geriatrik
(författare)
Immunotherapy targeting alpha-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-229388
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229388URI
-
https://doi.org/10.2217/IMT.13.162DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:for swepub-publicationtype
Anmärkningar
-
Immunotherapy targeting a-synuclein has evolved as a potential therapeutic strategy for neurodegenerative diseases, such as Parkinson's disease, and initial studies on cellular and animal models have shown promising results. alpha-synuclein vaccination of transgenic mice reduced the number of brain inclusions, whereas passive immunization studies demonstrated that antibodies against the C-terminus of alpha-synuclein can pass the blood-brain barrier and affect the pathology. In addition, preliminary evidence suggests that transgenic mice treated with an antibody directed against alpha-synuclein oligomers/protofibrils resulted in reduced levels of such species in the CNS. The underlying mechanisms of immunotherapy are not yet fully understood, but may include antibody-mediated clearance of pre-existing aggregates, prevention of protein propagation between cells and microglia-dependent protein clearance. Thus, immunotherapy targeting alpha-synuclein holds promise, but needs to be further developed as a future disease-modifying treatment in Parkinson's disease and other alpha-synucleinopathies.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Ihse, ElisabetUppsala universitet,Geriatrik(Swepub:uu)elihs048
(författare)
-
Fagerqvist, ThereseUppsala universitet,Geriatrik(Swepub:uu)thewa743
(författare)
-
Bergström, JoakimUppsala universitet,Geriatrik(Swepub:uu)joakberg
(författare)
-
Nordstrom, Eva
(författare)
-
Moller, Christer
(författare)
-
Lannfelt, LarsUppsala universitet,Geriatrik(Swepub:uu)lalan021
(författare)
-
Ingelsson, MartinUppsala universitet,Geriatrik(Swepub:uu)maing121
(författare)
-
Uppsala universitetGeriatrik
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Immunotherapy6:2, s. 141-1531750-743X1750-7448
Internetlänk
Hitta via bibliotek
Till lärosätets databas