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Comparison of zebra...
Comparison of zebrafish (Danio rerio) and fathead minnow (Pimephales promelas) as test species in the Fish Sexual Development Test (FSDT).
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Holbech, Henrik (författare)
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Kinnberg, Karin L (författare)
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Brande-Lavridsen, Nanna (författare)
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visa fler...
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Bjerregaard, Poul (författare)
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Petersen, Gitte I (författare)
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- Norrgren, Leif (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health
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- Örn, Stefan (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health
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Braunbeck, Thomas (författare)
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Baumann, Lisa (författare)
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Bomke, Christiane (författare)
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Dorgerloh, Michael (författare)
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Bruns, Eric (författare)
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Ruehl-Fehlert, Christine (författare)
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Green, John W (författare)
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Springer, Timothy A (författare)
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Gourmelon, Anne (författare)
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(creator_code:org_t)
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- Elsevier BV, 2012
- 2012
- Engelska.
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Ingår i: Comparative Biochemistry and Physiology - Part C. - : Elsevier BV. - 1532-0456 .- 1878-1659. ; 155:2, s. 407-15
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://res.slu.se/i...
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Abstract
Ämnesord
Stäng
- Results are presented from a validation (with 5 laboratories) of the Fish Sexual Development Test (FSDT) developed to detect endocrine disrupters (EDs) and included in the OECD (Organisation for Economic Co-operation and Development) working program. The aromatase-inhibiting fungicide prochloraz was tested in zebrafish (Danio rerio) and fathead minnow (Pimephales promelas). The fish were exposed during sexual differentiation and development from 0 to 60 days post hatch (dph). After exposure, the vitellogenin (VTG) concentrations were quantified in head/tail homogenate and the sex ratio was determined (defined as female, male, intersex or undifferentiated). NOEC/LOEC and EC(x) designs were compared to optimize the test approach. Results show that both species are highly sensitive to prochloraz during sexual development. They respond by skewing of the sex ratio towards male phenotype and by a VTG decline in females. The NOEC/LOEC approach is preferred because sex ratio is difficult to analyze with a regression model. The mean NOEC/LOEC for prochloraz on the sex ratio was 43.3/134 μg/L and 101/293 μg/L for zebrafish and fathead minnow, respectively. The mean NOEC/LOEC on the decline in female VTG concentration was 65/110 μg/L and ~30/68 μg/L respectively. In conclusion, zebrafish and fathead minnow are suitable species in the FSDT and their sexual differentiation is equally labile to EDs.
Ämnesord
- LANTBRUKSVETENSKAPER -- Annan lantbruksvetenskap -- Miljö- och naturvårdsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Other Agricultural Sciences -- Environmental Sciences related to Agriculture and Land-use (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Holbech, Henrik
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Kinnberg, Karin ...
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Brande-Lavridsen ...
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Bjerregaard, Pou ...
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Petersen, Gitte ...
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Norrgren, Leif
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visa fler...
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Örn, Stefan
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Braunbeck, Thoma ...
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Baumann, Lisa
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Bomke, Christian ...
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Dorgerloh, Micha ...
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Bruns, Eric
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Ruehl-Fehlert, C ...
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Green, John W
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Springer, Timoth ...
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Gourmelon, Anne
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visa färre...
- Om ämnet
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- LANTBRUKSVETENSKAPER
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LANTBRUKSVETENSK ...
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och Annan lantbruksv ...
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och Miljö och naturv ...
- Artiklar i publikationen
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Comparative Bioc ...
- Av lärosätet
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Uppsala universitet
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Sveriges Lantbruksuniversitet