Sökning: onr:"swepub:oai:DiVA.org:uu-256241" > The Shepherds' Tale :
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 06481naa a2200661 4500 | |
001 | oai:DiVA.org:uu-256241 | |
003 | SwePub | |
008 | 150622s2015 | |||||||||||000 ||eng| | |
009 | oai:slubar.slu.se:68702 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2562412 URI |
024 | 7 | a https://doi.org/10.1371/journal.pone.01231732 DOI |
024 | 7 | a https://res.slu.se/id/publ/687022 URI |
040 | a (SwePub)uud (SwePub)slu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Forsberg, Simonu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences4 aut0 (Swepub:slu)47020 |
245 | 1 0 | a The Shepherds' Tale :b A Genome-Wide Study across 9 Dog Breeds Implicates Two Loci in the Regulation of Fructosamine Serum Concentration in Belgian Shepherds |
264 | c 2015-05-13 | |
264 | 1 | b Public Library of Science (PLoS),c 2015 |
338 | a electronic2 rdacarrier | |
520 | a Diabetes mellitus is a serious health problem in both dogs and humans. Certain dog breeds show high prevalence of the disease, whereas other breeds are at low risk. Fructosamine and glycated haemoglobin (HbA1c) are two major biomarkers of glycaemia, where serum concentrations reflect glucose turnover over the past few weeks to months. In this study, we searched for genetic factors influencing variation in serum fructosamine concentration in healthy dogs using data from nine dog breeds. Considering all breeds together, we did not find any genome-wide significant associations to fructosamine serum concentration. However, by performing breed-specific analyses we revealed an association on chromosome 3 (rho(corrected) approximate to 1:68 x 10(-6)) in Belgian shepherd dogs of the Malinois subtype. The associated region and its close neighbourhood harbours interesting candidate genes such as LETM1 and GAPDH that are important in glucose metabolism and have previously been implicated in the aetiology of diabetes mellitus. To further explore the genetics of this breed specificity, we screened the genome for reduced heterozygosity stretches private to the Belgian shepherd breed. This revealed a region with reduced heterozygosity that shows a statistically significant interaction (rho = 0.025) with the association region on chromosome 3. This region also harbours some interesting candidate genes and regulatory regions but the exact mechanisms underlying the interaction are still unknown. Nevertheless, this finding provides a plausible explanation for breed-specific genetic effects for complex traits in dogs. Shepherd breeds are at low risk of developing diabetes mellitus. The findings in Belgian shepherds could be connected to a protective mechanism against the disease. Further insight into the regulation of glucose metabolism could improve diagnostic and therapeutic methods for diabetes mellitus. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a LANTBRUKSVETENSKAPERx Veterinärmedicinx Annan veterinärmedicin0 (SwePub)403042 hsv//swe |
650 | 7 | a AGRICULTURAL SCIENCESx Veterinary Sciencex Other Veterinary Science0 (SwePub)403042 hsv//eng |
700 | 1 | a Kierczak, Marcinu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Uppsala University4 aut0 (Swepub:slu)49557 |
700 | 1 | a Ljungvall, Ingridu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences4 aut0 (Swepub:slu)48949 |
700 | 1 | a Merveille, Anne-Christine4 aut |
700 | 1 | a Gouni, Vassiliki4 aut |
700 | 1 | a Wiberg, Maria4 aut |
700 | 1 | a Willesen, Jakob Lundgren4 aut |
700 | 1 | a Hanås, Sofiau Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Evidensia Animal Clinic Västerås4 aut0 (Swepub:slu)109904 |
700 | 1 | a Lequarre, Anne-Sophie4 aut |
700 | 1 | a Sorensen, Louise Mejer4 aut |
700 | 1 | a Tiret, Laurent4 aut |
700 | 1 | a McEntee, Kathleen4 aut |
700 | 1 | a Seppala, Eija4 aut |
700 | 1 | a Koch, Jorgen4 aut |
700 | 1 | a Battaille, Geraldine4 aut |
700 | 1 | a Lohi, Hannes4 aut |
700 | 1 | a Fredholm, Merete4 aut |
700 | 1 | a Chetboul, Valerie4 aut |
700 | 1 | a Häggström, Jensu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences4 aut0 (Swepub:slu)48327 |
700 | 1 | a Carlborg, Örjanu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Swedish University of Agricultural Sciences, Uppsala, Sweden4 aut0 (Swepub:slu)48083 |
700 | 1 | a Lindblad-Toh, Kerstinu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)kerli865 |
700 | 1 | a Höglund, Katjau Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB)4 aut0 (Swepub:slu)48365 |
710 | 2 | a Sveriges lantbruksuniversitetb Institutionen för kliniska vetenskaper (KV)4 org |
710 | 2 | a Sveriges lantbruksuniversitet |
773 | 0 | t PLOS ONEd : Public Library of Science (PLoS)g 10:5q 10:5x 1932-6203 |
856 | 4 | u https://doi.org/10.1371/journal.pone.0123173y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:825786/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0123173&type=printable |
856 | 4 | u https://pub.epsilon.slu.se/id/eprint/12816/contentsx primaryx Raw objectx freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-256241 |
856 | 4 8 | u https://doi.org/10.1371/journal.pone.0123173 |
856 | 4 8 | u https://res.slu.se/id/publ/68702 |
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