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Heritability of end...
Heritability of endometriosis
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- Saha, Rama (författare)
- Karolinska Institutet
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- Pettersson, Hans Järnbert (författare)
- Karolinska Institutet
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- Svedberg, Pia (författare)
- Karolinska Institutet
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- Olovsson, Matts, 1958- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Reproduktionsbiologi
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Bergqvist, Agneta (författare)
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- Marions, Lena (författare)
- Karolinska Institutet
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- Tornvall, Per (författare)
- Karolinska Institutet
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- Kuja-Halkola, Ralf (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- Engelska.
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Ingår i: Fertility and Sterility. - : Elsevier BV. - 0015-0282 .- 1556-5653. ; 104:4, s. 947-952
- Relaterad länk:
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http://www.fertstert...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To estimate the relative contribution of genetic influences and prevalence on endometriosis.DESIGN: Analysis of self-reported data from a nationwide population-based twin registry.SETTING: Not applicable.PATIENT(S): A total of 28,370 women, female monozygotic (MZ) or dizygotic (DZ) twins, who participated in either of two surveys (1998-2002 or 2005-2006).INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): Self-reported endometriosis, validated by medical records.RESULT(S): A history of endometriosis was reported by 1,228 female twins. The probandwise concordance was 0.21 for MZ and 0.10 for DZ twins. Higher within-pair (tetrachoric) correlation was observed among MZ (0.47) compared with DZ (0.20) twins. The best-fitting model revealed a contribution of 47% by additive genetic factors and the remaining 53% attributed to unique environmental effects.CONCLUSION(S): Our findings suggest both genetic and unique (nonshared) environmental influences on the complex etiology of endometriosis and support the hypothesis that genes have a strong influence on phenotypic manifestations of endometriosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Concordance; endometriosis; heritability; twins
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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