Synthesis of C-branched spermine tethered oligo-DNA and the thermal stability of the duplexes and triplexes

• The first synthesis of the new C-branched spermine derivative 17, as well as its ability to stabilise DNA duplexes and triplexes, are reported. The C-branched spermine block 17 was converted into the corresponding O-(2-cyanoethyl)-(N,N-diisopropyl)phospho

Nyckelord

NUCLEAR MAGNETIC-RESONANCE; HELIX FORMATION; STRANDED DNA; OLIGONUCLEOTIDES; POLYAMINES; SEQUENCE; STABILIZATION; DERIVATIVES; REAGENTS; BINDING

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