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Cytoreductive surge...
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Cashin, Peter H.Uppsala universitet,Kolorektalkirurgi
(författare)
Cytoreductive surgery and intraperitoneal chemotherapy versus systemic chemotherapy for colorectal peritoneal metastases : A randomised trial
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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Elsevier BV,2016
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-280096
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280096URI
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https://doi.org/10.1016/j.ejca.2015.09.017DOI
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https://lup.lub.lu.se/record/8592453URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:132854040URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: First-line treatment of isolated resectable colorectal peritoneal metastases remains unclear. This study (the Swedish peritoneal study) compares cytoreductive surgery and intraperitoneal chemotherapy (surgery arm) with systemic chemotherapy (chemotherapy arm). Methods: Patients deemed resectable preoperatively were randomised to surgery and intraperitoneal 5-fluorouracil 550 mg/m(2) /d for 6 d with repeated courses every month or to systemic oxaliplatin and 5-fluorouracil regimen every second week. Both treatments continued for 6 months. Primary end-point was overall survival (OS) and secondary end-points were progression-free survival (PFS), and morbidity. Results: The study terminated prematurely when 48 eligible patients (24/arm) were included due to recruitment difficulties. Two-year OS was 54% in the surgery arm and 38% in the chemotherapy arm (p = 0.04). After 5 years, 8 versus 1 patient were alive, respectively (p = 0.02). Median OS was 25 months versus 18 months, respectively, hazard ratio 0.51 (95% confidence interval: 0.27-0.96, p = 0.04). PFS in the surgery arm was 12 months versus 11 months in the chemotherapy arm (p = 0.16) with 17% versus 0% 5-year PFS. Grade III-IV morbidity was seen in 42% and 50% of the patients, respectively. No mortalities. Conclusions: Cytoreductive surgery with intraperitoneal chemotherapy may be superior to systemic oxaliplatin-based treatment of colorectal cancer with resectable isolated peritoneal metastases.(ClinicalTrials. gov nr: NCT01524094).
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mahteme, HaileUppsala universitet,Institutionen för kirurgiska vetenskaper,Uppsala Canc Clin, Uppsala, Sweden.(Swepub:uu)hailmaht
(författare)
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Spang, N.Uppsala universitet,Institutionen för kirurgiska vetenskaper
(författare)
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Syk, IngvarLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)kir-isy
(författare)
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Frodin, J. E.Karolinska Institutet
(författare)
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Torkzad, MichaelUppsala universitet,Radiologi
(författare)
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Glimelius, BengtUppsala universitet,Experimentell och klinisk onkologi,Karolinska Inst, Dept Pathol & Oncol, S-17176 Stockholm, Sweden.(Swepub:uu)bengglim
(författare)
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Graf, WilhelmUppsala universitet,Kolorektalkirurgi(Swepub:uu)wilhgraf
(författare)
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Uppsala universitetKolorektalkirurgi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Cancer: Elsevier BV53, s. 155-1620959-80491879-0852
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