Sökning: onr:"swepub:oai:DiVA.org:uu-303024" >
Fracture Rate, Qual...
Fracture Rate, Quality of Life and Back Pain in Patients with Osteoporosis Treated with Teriparatide : 24-Month Results from the Extended Forsteo Observational Study (ExFOS)
-
- Langdahl, Bente L. (författare)
- Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Tage Hansens Gade 2, DK-8000 Aarhus, Denmark.
-
- Ljunggren, Östen (författare)
- Uppsala universitet,Endokrinologi och mineralmetabolism
-
- Benhamou, Claude-Laurent (författare)
- Orleans Hosp, Orleans, France.
-
visa fler...
-
- Marin, Fernando (författare)
- Eli Lilly & Co, Windlesham, Surrey, England.
-
- Kapetanos, George (författare)
- Papageorgiou Gen Hosp, Thessaloniki, Greece.
-
- Kocjan, Tomaz (författare)
- Univ Med Ctr, Ljubljana, Slovenia.
-
- Lespessailles, Eric (författare)
- Orleans Hosp, Orleans, France.;Univ Orleans, EA 4708 I3MTO, Orleans, France.
-
- Napoli, Nicola (författare)
- Univ Campus Biomed, Rome, Italy.
-
- Nikolic, Tatjana (författare)
- Univ Hosp, Zagreb, Croatia.
-
- Petto, Helmut (författare)
- Eli Lilly & Co, Windlesham, Surrey, England.
-
- Moll, Thomas (författare)
- Eli Lilly & Co, Windlesham, Surrey, England.
-
- Lindh, Erik (författare)
- Eli Lilly & Co, Windlesham, Surrey, England.
-
visa färre...
-
Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Tage Hansens Gade 2, DK-8000 Aarhus, Denmark Endokrinologi och mineralmetabolism (creator_code:org_t)
- 2016-04-30
- 2016
- Engelska.
-
Ingår i: Calcified Tissue International. - : Springer Science and Business Media LLC. - 0171-967X .- 1432-0827. ; 99:3, s. 259-271
- Relaterad länk:
-
https://uu.diva-port... (primary) (Raw object)
-
visa fler...
-
https://europepmc.or...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- We describe the pre-planned interim analysis of fracture outcomes, health-related quality of life (HRQoL) and back pain in patients with severe osteoporosis treated with teriparatide for up to 24 months in the Extended Forsteo (Forsteo(A (R)) is a registered trade name of Eli Lilly and Company) Observational Study (ExFOS), a prospective, multinational, observational study. Data on incident clinical fractures, HRQoL (EQ-5D questionnaire) and back pain [100 mm visual analogue scale (VAS)] were collected. The number of patients with fractures was summarised in 6-month intervals and fracture rate over each 6-month period was assessed using logistic regression for repeated measures. Changes from baseline in EQ-5D and back pain VAS were analysed using mixed models for repeated measures. Of 1454 patients in the active treatment cohort, 90.6 % were female and 14.4 % were taking glucocorticoids. During teriparatide treatment (median duration 23.7 months), 103 patients (7.1 %) sustained a total of 122 incident clinical fractures (21 % vertebral, 79 % non-vertebral). A 49 % decrease in the odds of fractures and a 75 % decrease in the odds of clinical vertebral fractures were observed in the > 18- to 24-month period versus the first 6-month period (both p < 0.05). EQ-5D scores and back pain VAS scores were significantly improved from baseline at each post-baseline observation during teriparatide treatment. In conclusion, patients with severe osteoporosis showed a significant reduction in the incident fracture rate during 24 months of teriparatide treatment in routine clinical practice, accompanied by a significant improvement in HRQoL and reduction in back pain. Results should be interpreted in the context of the non-controlled design of this observational study.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Osteoporosis
- Observational study
- Teriparatide
- Fractures
- Quality of life
- Back pain
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Langdahl, Bente ...
-
Ljunggren, Östen
-
Benhamou, Claude ...
-
Marin, Fernando
-
Kapetanos, Georg ...
-
Kocjan, Tomaz
-
visa fler...
-
Lespessailles, E ...
-
Napoli, Nicola
-
Nikolic, Tatjana
-
Petto, Helmut
-
Moll, Thomas
-
Lindh, Erik
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Calcified Tissue ...
- Av lärosätet
-
Uppsala universitet