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  • Sepulveda, Jorge I. RamirezKarolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Expt Rheumatol, SE-17176 Stockholm, Sweden.,Karolinska University Hospital, Sweden (författare)

Long-term follow-up in primary Sjögren's syndrome reveals differences in clinical presentation between female and male patients

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017-08-08
  • BioMed Central,2017
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-334043
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-334043URI
  • https://doi.org/10.1186/s13293-017-0146-6DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138582URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-140049URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:136353801URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Jennifer Meadows is a member of the DISSECT consortium.
  • Funding Agencies|Swedish Research Council; Heart-Lung Foundation; Stockholm County Council; Karolinska Institutet; Swedish Rheumatism association; King Gustaf the Vth 80-year foundation; AstraZeneca Science for Life Laboratory Research Collaboration grant
  • Background: Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune diseases. In the present study, we aimed to investigate differences in the clinical presentation of primary Sjogren's syndrome (pSS) between the sexes and establish whether male sex is associated with a more severe form of long-term pSS. Methods: Our study population included 967 patients with pSS (899 females and 68 males) from Scandinavian clinical centers. The mean follow-up time (years) was 8.8 +/- 7.6 for women and 8.5 +/- 6.2 for men (ns). Clinical data including serological and hematological parameters and glandular and extraglandular manifestations were compared between men and women. Results: Male patient serology was characterized by more frequent positivity for anti-Ro/SSA and anti-La/SSB (p = 0. 02), and ANA (p = 0.02). Further, men with pSS were more frequently diagnosed with interstitial lung disease (p = 0. 008), lymphadenopathy (p = 0.04) and lymphoma (p = 0.007). Conversely, concomitant hypothyroidism was more common among female patients (p = 0.009). Conclusions: We observe enhanced serological responses and higher frequencies of lymphoma-related extraglandular manifestations in men with pSS. Notably, lymphoma itself was also significantly more common in men. These observations may reflect an aggravated immune activation and a more severe pathophysiological state in male patients with pSS and indicate a personalized managing of the disease due to the influence of the sex of patients with pSS.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Kvarnstrom, MarikaKarolinska Institutet (författare)
  • Eriksson, PerLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland,Linköping Univ, Div Rheumatol, Dept Clin Expt Med, Linköping, Sweden.(Swepub:liu)perer22 (författare)
  • Mandl, ThomasSkane Univ Hosp, Dept Rheumatol, Malmö, Sweden.,Skåne University Hospital, Sweden (författare)
  • Norheim, Katrine BraekkeStavanger Univ Hosp, Dept Internal Med, Clin Immunol Unit, Stavanger, Norway.,Stavanger University Hospital, Norway (författare)
  • Johnsen, Svein JoarStavanger Univ Hosp, Dept Internal Med, Clin Immunol Unit, Stavanger, Norway.,Stavanger University Hospital, Norway (författare)
  • Hammenfors, DanielUniv Bergen, Dept Clin Sci, Broegelmann Res Lab, Bergen, Norway.;Haukeland Hosp, Dept Rheumatol, Bergen, Norway.,University of Bergen, Norway; Haukeland Hospital, Norway (författare)
  • Jonsson, Malin V.Univ Bergen, Dept Clin Sci, Broegelmann Res Lab, Bergen, Norway.;Univ Bergen, Sect Oral & Maxillofacial Radiol, Dept Clin Dent, Bergen, Norway.,University of Bergen, Norway; University of Bergen, Norway (författare)
  • Skarstein, KathrineUniv Bergen, Dept Clin Med, Gade Lab Pathol, Bergen, Norway.;Haukeland Hosp, Dept Pathol, Bergen, Norway.,University of Bergen, Norway; Haukeland Hospital, Norway (författare)
  • Brun, Johan G.Univ Bergen, Dept Clin Sci, Broegelmann Res Lab, Bergen, Norway.;Haukeland Hosp, Dept Rheumatol, Bergen, Norway.,University of Bergen, Norway; Haukeland Hospital, Norway (författare)
  • Rönnblom, LarsUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden(Swepub:uu)larsronn (författare)
  • Forsblad-d'Elia, HelenaUmeå universitet,Reumatologi,Umeå University, Sweden,Umeå Univ, Dept Publ Hlth & Clin Med, Rheumatol, Umeå, Sweden.(Swepub:umu)hefo0034 (författare)
  • Bucher, Sara MagnussonÖrebro Univ, Fac Med & Hlth, Dept Rheumatol, Örebro, Sweden.,Örebro University, Sweden (författare)
  • Baecklund, Eva,1956-Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden(Swepub:uu)evaba786 (författare)
  • Theander, ElkeSkane Univ Hosp, Dept Rheumatol, Malmö, Sweden.,Skåne University Hospital, Sweden (författare)
  • Omdal, RoaldStavanger Univ Hosp, Dept Internal Med, Clin Immunol Unit, Stavanger, Norway.,Stavanger University Hospital, Norway (författare)
  • Jonsson, RolandUniv Bergen, Dept Clin Sci, Broegelmann Res Lab, Bergen, Norway.;Haukeland Hosp, Dept Rheumatol, Bergen, Norway.,University of Bergen, Norway; Haukeland Hospital, Norway (författare)
  • Nordmark, GunnelUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden(Swepub:uu)gunnnord (författare)
  • Wahren-Herlenius, MarieKarolinska Institutet (författare)
  • Meadows, JenniferUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,DISSECT consortium(Swepub:uu)jenme818 (bidragsgivare)
  • Dahlqvist, Johanna,1979-Uppsala universitet,Reumatologi,DISSECT consortium(Swepub:uu)johda205 (bidragsgivare)
  • Karolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Expt Rheumatol, SE-17176 Stockholm, Sweden.Karolinska University Hospital, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Biology of Sex Differences: BioMed Central82042-6410

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