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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003971naa a2200541 4500
001oai:DiVA.org:uu-336245
003SwePub
008171213s2017 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-136189
009oai:prod.swepub.kib.ki.se:135784161
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3362452 URI
0247 a https://doi.org/10.1038/s41598-017-01553-22 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1361892 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1357841612 URI
040 a (SwePub)uud (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Schwartzbaum, Judith4 aut
2451 0a Associations between prediagnostic blood glucose levels, diabetes, and glioma.
264 c 2017-05-03
264 1b Springer Science and Business Media LLC,c 2017
338 a print2 rdacarrier
520 a Previous literature indicates that pre-diagnostic diabetes and blood glucose levels are inversely related to glioma risk. To replicate these findings and determine whether they could be attributed to excess glucose consumption by the preclinical tumour, we used data from the Apolipoprotein MOrtality RISk (AMORIS) (n = 528,580) and the Metabolic syndrome and Cancer project (Me-Can) cohorts (n = 269,365). We identified individuals who were followed for a maximum of 15 years after their first blood glucose test until glioma diagnosis, death, emigration or the end of follow-up. Hazard ratios (HRs), 95% confidence intervals (CIs) and their interactions with time were estimated using Cox time-dependent regression. As expected, pre-diagnostic blood glucose levels were inversely related to glioma risk (AMORIS, P trend = 0.002; Me-Can, P trend = 0.04) and pre-diagnostic diabetes (AMORIS, HR = 0.30, 95% CI 0.17 to 0.53). During the year before diagnosis, blood glucose was inversely associated with glioma in the AMORIS (HR = 0.78, 95% CI 0.66 to 0.93) but not the Me-Can cohort (HR = 0.99, 95% CI 0.63 to 1.56). This AMORIS result is consistent with our hypothesis that excess glucose consumption by the preclinical tumour accounts for the inverse association between blood glucose and glioma. We discuss additional hypothetical mechanisms that may explain our paradoxical findings.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Edlinger, Michael4 aut
7001 a Zigmont, Victoria4 aut
7001 a Stattin, Päru Umeå universitet,Uppsala universitet,Urologkirurgi,Urologi och andrologi4 aut0 (Swepub:umu)past0003
7001 a Rempala, Grzegorz A4 aut
7001 a Nagel, Gabriele4 aut
7001 a Hammar, Niklasu Karolinska Institutet4 aut
7001 a Ulmer, Hanno4 aut
7001 a Föger, Bernhard4 aut
7001 a Walldius, Göranu Karolinska Institutet4 aut
7001 a Manjer, Jonas4 aut
7001 a Malmström, Håkanu Karolinska Institutet4 aut
7001 a Feychting, Mariau Karolinska Institutet4 aut
7102 a Uppsala universitetb Urologkirurgi4 org
7730 t Scientific Reportsd : Springer Science and Business Media LLCg 7:1q 7:1x 2045-2322
8564 u https://www.nature.com/articles/s41598-017-01553-2.pdf
8564 u https://doi.org/10.1038/s41598-017-01553-2y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1120811/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-336245
8564 8u https://doi.org/10.1038/s41598-017-01553-2
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-136189
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:135784161

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