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Adjusted Troponin I...
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Boeckel, Jes-NielsGoethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, Frankfurt, Germany;Univ Hosp Leipzig, Dept Internal Med, Cardiol, Leipzig, Germany
(författare)
Adjusted Troponin I for Improved Evaluation of Patients with Chest Pain
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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NATURE PUBLISHING GROUP,2018
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-357270
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-357270URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The use of cardiac troponins (cTn) is the gold standard for diagnosing myocardial infarction. Independent of myocardial infarction (MI), however, sex, age and kidney function affect cTn levels. Here we developed a method to adjust cTnI levels for age, sex, and renal function, maintaining a unified cut-off value such as the 99th percentile. A total of 4587 individuals enrolled in a prospective longitudinal study were used to develop a model for adjustment of cTn. cTnI levels correlated with age and estimated glomerular filtration rate (eGFR) in males/females with r(age) = 0.436/0.518 and with (r)(eGFR) = -0.142/-0.207. For adjustment, these variables served as covariates in a linear regression model with cTnl as dependent variable. This adjustment model was then applied to a real-world cohort of 1789 patients with suspected acute MI (AMI) (N = 407). Adjusting cTnI showed no relevant loss of diagnostic information, as evidenced by comparable areas under the receiver operator characteristic curves, to identify AMI in males and females for adjusted and unadjusted cTnI. In specific patients groups such as in elderly females, adjusting cTnI improved specificity for AMI compared with unadjusted cTnI. Specificity was also improved in patients with renal dysfunction by using the adjusted cTnI values. Thus, the adjustments improved the diagnostic ability of cTnI to identify AMI in elderly patients and in patients with renal dysfunction. Interpretation of cTnI values in complex emergency cases is facilitated by our method, which maintains a single diagnostic cut-off value in all patients.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Palapies, LarsGoethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany
(författare)
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Klotsche, JensTech Univ Dresden, Clin Psychol & Psychotherapy, Dresden, Germany
(författare)
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Zeller, TanjaGerman Ctr Cardiovasc Dis DZHK, Berlin, Germany;Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany
(författare)
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von Jeinsen, BeatriceGoethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany
(författare)
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Perret, Maya F.Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany
(författare)
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Kleinhaus, Soeren L.Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, Frankfurt, Germany
(författare)
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Pieper, LarsTech Univ Dresden, Clin Psychol & Psychotherapy, Dresden, Germany
(författare)
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Tzikas, StergiosAristotle Univ Thessaloniki, Ippokrateio Hosp, Dept Cardiol 3, Thessaloniki, Greece;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 2, Mainz, Germany
(författare)
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Leistner, DavidGoethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany
(författare)
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Bickel, ChristophFed Armed Forces Hosp, Dept Internal Med, Koblenz, Germany
(författare)
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Stalla, Guenter K.Max Planck Inst Psychiat, Neuroendocrinol, Munich, Germany
(författare)
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Lehnert, HendrikUniv Hosp Schleswig Holstein, Dept Internal Med 1, Lubeck, Germany
(författare)
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Lindahl, Bertil,1957-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)belin227
(författare)
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Wittchen, Hans-UlrichTech Univ Dresden, Clin Psychol & Psychotherapy, Dresden, Germany
(författare)
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Silber, SigmundPraxisklin, Kardiol Gemeinschaftspraxis, Munich, Germany
(författare)
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Baldus, StephanUniv Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany;Univ Cologne, Heart Ctr, Cologne, Germany
(författare)
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Maerz, WinfriedSynlab Serv GmbH, Synlab Akad Arztl Fortbildung, Mannheim, Germany
(författare)
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Dimmeler, StefanieGerman Ctr Cardiovasc Dis DZHK, Berlin, Germany;Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, Frankfurt, Germany
(författare)
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Blankenberg, StefanGerman Ctr Cardiovasc Dis DZHK, Berlin, Germany;Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany
(författare)
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Muenzel, ThomasGerman Ctr Cardiovasc Dis DZHK, Berlin, Germany;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 2, Mainz, Germany
(författare)
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Zeiher, Andreas M.Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany
(författare)
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Keller, TillGoethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Kerckhoff Heart & Thorax Ctr, Bad Nauheim, Germany
(författare)
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Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, Frankfurt, Germany;Univ Hosp Leipzig, Dept Internal Med, Cardiol, Leipzig, GermanyGoethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scientific Reports: NATURE PUBLISHING GROUP82045-2322
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Boeckel, Jes-Nie ...
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Palapies, Lars
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Klotsche, Jens
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Zeller, Tanja
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von Jeinsen, Bea ...
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Perret, Maya F.
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visa fler...
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Kleinhaus, Soere ...
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Pieper, Lars
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Tzikas, Stergios
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Leistner, David
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Bickel, Christop ...
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Stalla, Guenter ...
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Lehnert, Hendrik
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Lindahl, Bertil, ...
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Wittchen, Hans-U ...
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Silber, Sigmund
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Baldus, Stephan
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Maerz, Winfried
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Dimmeler, Stefan ...
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Blankenberg, Ste ...
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Muenzel, Thomas
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Zeiher, Andreas ...
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Keller, Till
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visa färre...
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och Klinisk medicin
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