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Steroid regulation :
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Christakoudi, SofiaKings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, Biostat & Hlth Informat Dept, 16 Crespigny Pk, London SE5 8AF, England
(författare)
Steroid regulation : An overlooked aspect of tolerance and chronic rejection in kidney transplantation
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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ELSEVIER IRELAND LTD,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-369512
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-369512URI
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https://doi.org/10.1016/j.mce.2018.01.021DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Steroid conversion (HSD11B1, HSD11B2, H6PD) and receptor genes (NR3C1, NR3C2) were examined in kidney-transplant recipients with "operational tolerance" and chronic rejection (CR), independently and within the context of 88 tolerance-associated genes. Associations with cellular types were explored. Peripheral whole-blood gene-expression levels (RT-qPCR-based) and cell counts were adjusted for immunosuppressant drug intake. Tolerant (n = 17), stable (n = 190) and CR patients (n = 37) were compared. Healthy controls (n= 14) were used as reference. The anti-inflammatory glucocorticoid receptor (NR3C1) and the cortisol-activating HSD11B1 and H6PD genes were up-regulated in CR and were lowest in tolerant patients. The pro-inflammatory mineralocorticoid gene (NR3C2) was downregulated in stable and CR patients. NR3C1 was associated with neutrophils and NR3C2 with T-cells. Steroid conversion and receptor genes, alone, enabled classification of tolerant patients and were major contributors to gene-expression signatures of both, tolerance and CR, alongside known tolerance-associated genes, revealing a key role of steroid regulation and response in kidney transplantation.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Runglall, ManohursinghGuys & St Thomas NHS Fdn Trust, NIHR Biomed Res Ctr, London SE1 9RT, England;Kings Coll London, London SE1 9RT, England
(författare)
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Mobillo, PaulaKings Coll London, MRC Ctr Transplantat, London SE1 9RT, England
(författare)
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Rebollo-Mesa, IreneKings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, Biostat & Hlth Informat Dept, 16 Crespigny Pk, London SE5 8AF, England;UCB Pharma SA, UCB Celltech, Brussels, Belgium
(författare)
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Tsui, Tjir-LiKings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Guys & St Thomas NHS Fdn Trust, London SE1 9RT, England
(författare)
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Nova-Lamperti, EstefaniaKings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Univ Concepcion, Pharm Fac, Dept Clin Biochem & Immunol, Lab Mol & Translat Immunol, Concepcion, Chile
(författare)
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Norris, SoniaKings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;UCL, London, England
(författare)
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Kamra, YogeshKings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Kings Coll London, Peter Gorer Dept Immunobiol, London, England
(författare)
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Hilton, RachelGuys & St Thomas NHS Fdn Trust, London SE1 9RT, England
(författare)
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Bhandari, SunilHull & East Yorkshire Hosp NHS Trust, Anlaby Rd, Kingston Upon Hull HU3 2JZ, N Humberside, England
(författare)
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Baker, RichardSt James Univ Hosp, Beckett St, Leeds LS9 7TF, W Yorkshire, England
(författare)
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Berglund, David,1984-Uppsala universitet,Klinisk immunologi(Swepub:uu)davbe892
(författare)
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Carr, SueLeicester Gen Hosp, Gwendolen Rd, Leicester LE5 4PW, Leics, England
(författare)
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Game, DavidGuys & St Thomas NHS Fdn Trust, London SE1 9RT, England
(författare)
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Griffin, SianCardiff & Vale Univ Hlth Board, Cardiff CF14 4XW, S Glam, Wales
(författare)
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Kalra, Philip A.Salford Royal NHS Fdn Trust, Stott Ln, Salford M6 8HD, Lancs, England
(författare)
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Lewis, RobertQueen Alexandra Hosp, Southwick Hill Rd, Portsmouth PO6 3LY, Hants, England
(författare)
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Mark, Patrick B.Univ Glasgow, Univ Ave, Glasgow G12 8QQ, Lanark, Scotland
(författare)
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Marks, Stephen D.Great Ormond St Hosp Children NHS Fdn Trust, Great Ormond St,London, London WC1N 3JH, England
(författare)
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Macphee, LainSt George Hosp, Blackshaw Rd, London SW17 0QT, England
(författare)
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McKane, WilliamNorthern Gen Hosp, Herries Rd, Sheffield S5 7AU, S Yorkshire, England
(författare)
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Mohaupt, Markus G.Univ Hosp, Univ Spital Dept Nephrol Hypertens & Clin Pharmac, INSELSPITAL, Freiburgstr 8, CH-3010 Bern, Switzerland
(författare)
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Pararajasingam, RaviManchester Royal Infirm, Oxford Rd, Manchester M13 9WL, Lancs, England
(författare)
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Kon, Sui PhinKings Coll Hosp NHS Fdn Trust, Denmark Hill, London SE5 9RS, England
(författare)
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Seron, DanielHosp Univ Vali dHebron, Passeig Vali dHebron 119-129, Barcelona 08035, Spain
(författare)
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Sinha, ManishEvelina London Childrens Hosp, Westminster Bridge Rd, London SE1 7EH, England
(författare)
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Tucker, BeatrizKings Coll Hosp NHS Fdn Trust, Denmark Hill, London SE5 9RS, England
(författare)
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Viklicky, OndrejIKEM, Transplantacni Lab, Videnska 1958-9, Prague 14021 4, Czech Republic
(författare)
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Lechler, Robert, IKings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Guys Hosp, Kings Hlth Partners, London SE1 9RT, England
(författare)
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Lord, Graham M.Kings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Guys & St Thomas NHS Fdn Trust, NIHR Biomed Res Ctr, London SE1 9RT, England;Kings Coll London, London SE1 9RT, England;Guys & St Thomas NHS Fdn Trust, London SE1 9RT, England
(författare)
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Stahl, DanielKings Coll London, Inst Psychiat Psychol & Neurosci, Biostat & Hlth Informat Dept, 16 Crespigny Pk, London SE5 8AF, England
(författare)
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Hernandez-Fuentes, Maria P.Kings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Guys Hosp, Kings Hlth Partners, London SE1 9RT, England;UCB Pharma SA, UCB Celltech, Brussels, Belgium
(författare)
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Kings Coll London, MRC Ctr Transplantat, London SE1 9RT, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, Biostat & Hlth Informat Dept, 16 Crespigny Pk, London SE5 8AF, EnglandGuys & St Thomas NHS Fdn Trust, NIHR Biomed Res Ctr, London SE1 9RT, England;Kings Coll London, London SE1 9RT, England
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Molecular and Cellular Endocrinology: ELSEVIER IRELAND LTD473, s. 205-2160303-72071872-8057
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Till lärosätets databas
- Av författaren/redakt...
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Christakoudi, So ...
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Runglall, Manohu ...
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Mobillo, Paula
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Rebollo-Mesa, Ir ...
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Tsui, Tjir-Li
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Nova-Lamperti, E ...
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visa fler...
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Norris, Sonia
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Kamra, Yogesh
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Hilton, Rachel
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Bhandari, Sunil
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Baker, Richard
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Berglund, David, ...
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Carr, Sue
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Game, David
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Griffin, Sian
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Kalra, Philip A.
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Lewis, Robert
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Mark, Patrick B.
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Marks, Stephen D ...
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Macphee, Lain
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McKane, William
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Mohaupt, Markus ...
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Pararajasingam, ...
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Kon, Sui Phin
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Seron, Daniel
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Sinha, Manish
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Tucker, Beatriz
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Viklicky, Ondrej
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Lechler, Robert, ...
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Lord, Graham M.
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Stahl, Daniel
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Hernandez-Fuente ...
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