onr:"swepub:oai:DiVA.org:uu-372919"
Sökning: onr:"swepub:oai:DiVA.org:uu-372919" > Late vertebral side...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Late vertebral side effects in long-term survivors of irradiated childhood brain tumor
-
- Jussila, Miro-Pekka (författare)
- Univ Oulu, Res Unit Med Imaging Phys & Technol, Fac Med, Oulu, Finland;Univ Oulu, Med Res Ctr, Oulu, Finland
-
- Remes, Tiina (författare)
- Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland;Oulu Univ Hosp, PEDEGO Res Unit, Oulu, Finland;Univ Oulu, Oulu, Finland
-
- Anttonen, Julia (författare)
- Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland;Oulu Univ Hosp, PEDEGO Res Unit, Oulu, Finland;Univ Oulu, Oulu, Finland
- visa fler...
- visa färre...
- (creator_code:org_t)
- 2018-12-18
- 2018
- Engelska.
- Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 13:12
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Purpose: Long-term side effects of the treatments are common in survivors of irradiated pediatric brain tumors. Ionizing radiation in combination with surgery and chemotherapy during childhood may reduce vertebral height and bone mineral density (BMD), and cause growth failure. The aim of this study was to evaluate the late consequences of tumor treatments on vertebrae in survivors of childhood brain tumors.Methods: 72 adult survivors (mean age 27.8 years, standard deviation 6.7) of irradiated childhood brain tumor were studied by spinal magnetic resonance imaging (MRI) for vertebral abnormalities from the national cohort of Finland. Patients were treated in five university hospitals in Finland between the years 1970 and 2008. Subject height and weight were measured and body mass index (BMI) was calculated. The morphology and height/ depth ratio of the vertebrae in the middle of the kyphotic thoracic curvature (Th8) and lumbar lordosis (L3) were examined. Vertebrae were analyzed by Genant's semiquantative (SQ) method and spinal deformity index (SDI) was calculated. BMD was measured by using dual X-ray absorptiometry.Results: 4.2% (3/72) of the patients had undiagnosed asymptomatic vertebral fracture and 5.6% (4/72) of patients had radiation- induced decreased vertebral body height. Male patients had flatter vertebrae compared with females. Patient age at the time of irradiation, BMI and irradiation area correlated to vertebral morphology differentially in males and females. BMD had no association with the vertebral shape. Patients who had received craniospinal irradiation were shorter than the general population.Conclusion: Childhood brain tumor survivors had a high number of vertebral abnormalities in young adulthood. Irradiation was associated with abnormal vertebral morphology and compromised final height. Male gender may predispose vertebrae to the side effects of irradiation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Jussila, Miro-Pe ...
- Remes, Tiina
- Anttonen, Julia
- Harila-Saari, Ar ...
- Niinimaki, Jaakk ...
- Pokka, Tytti
- visa fler...
- Koskenkorva, Pai ...
- Sutela, Anna
- Toiviainen-Sale, ...
- Arikoski, Pekka
- Riikonen, Pekka
- Arola, Mikko
- Lahteenmaki, Pai ...
- Sirkia, Kirsti
- Rantala, Heikki
- Suo-Palosaari, M ...
- Ojaniemi, Marja
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Radiologi och bi ...
- Artiklar i publikationen
- PLOS ONE
- Av lärosätet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
