onr:"swepub:oai:DiVA.org:uu-3732"
Sökning: onr:"swepub:oai:DiVA.org:uu-3732" > Mutation and Divers...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Sundström, Hannah,1975-Uppsala universitet,Institutionen för evolutionsbiologi (författare)
Mutation and Diversity in Avian Sex Chromosomes
- BokEngelska2003
Förlag, utgivningsår, omfång ...
- Uppsala :Acta Universitatis Upsaliensis,2003
- 66 s.
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-3732
- ISBN:9155457762
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3732URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Serie
- Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology,1104-232X ;900
Anmärkningar
- Sex chromosomes are useful for the study of how factors such as mutation, selection, recombination and effective population size affect diversity and divergence.A comparison of gametologous introns in seven different bird species revealed a complete lack of diversity on the female-specific W chromosome. In contrast, Z had at least one segregating site in all examined species. This can be explained by the lower mutation rate and lower effective population size of W but also suggests that selection affects diversity levels on the non-recombining W chromosome.In a diverse set of chicken breeds, the Z chromosome showed reduced diversity compared to autosomes and significant heterogeneity in levels of variation. High variance in male reproductive success, leading to a reduced Z chromosome effective population size, can partly explain this observation. In addition, we suggest that selective sweeps frequently act on the Z chromosome and are responsible for a significant part of the observed Z reduction. Differences in the mutation rate of Z and W chromosome sequences indicate that the time spent in male germ line is important for the mutation rate, but does not exclude a specifically reduced mutation rate on the Z chromosome. Estimates of mutation rate in autosomal, Z- and W-linked chicken and turkey sequences indicate a slight reduction in the rate on Z. However, due to rate heterogeneity among introns this reduction is not significant and we cannot exclude male biased mutation as the single cause of rate variation between the chromosomal classes.Analysis of indel mutation rates in avian and mammalian gametologous introns show frequent occurrence of indels on both W and Y, excluding meiotic recombination as the only source of this type of mutation. The different indel rate patterns in birds (Z>W) and mammals (X=Y) suggest that indels are caused by both replication and recombination.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
- Genetics
- mutation rate
- diversity
- sex chromosomes
- indels
- male bias
- selective sweep
- effective population size
- birds
- Genetik
- Clinical genetics
- Klinisk genetik
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Ellegren, Hans (preses)
- Burt, David W.,PhDDepartment of Genomics and Bioinformatics, Roslin Institute, Edinburgh (opponent)
- Uppsala universitetInstitutionen för evolutionsbiologi (creator_code:org_t)
Internetlänk
Hitta via bibliotek
- Mutation and Diversity in Avian Sex Chromosomes (Sök publikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Sundström, Hanna ...
- Ellegren, Hans
- Burt, David W., ...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Medicinsk geneti ...
- Delar i serien
- Comprehensive Su ...
- Av lärosätet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
