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Mood Disorders, Acc...
Mood Disorders, Accelerated Aging, and Inflammation : Is the Link Hidden in Telomeres?
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- Squassina, Alessio (författare)
- Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, I-09042 Monserrato, Italy;Dalhousie Univ, Dept Psychiat, Halifax, NS B3H 2E2, Canada
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- Pisanu, Claudia (författare)
- Uppsala universitet,Funktionell farmakologi,Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, I-09042 Monserrato, Italy
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- Vanni, Roberta (författare)
- Univ Cagliari, Unit Biol & Genet, Dept Biomed Sci, I-09042 Monserrato, Italy
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(creator_code:org_t)
- 2019-01-15
- 2019
- Engelska.
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Ingår i: Cells. - : MDPI. - 2073-4409. ; 8:1
- Relaterad länk:
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Mood disorders are associated with an increased risk of aging-related diseases, which greatly contribute to the excess morbidity and mortality observed in affected individuals. Clinical and molecular findings also suggest that mood disorders might be characterized by a permanent state of low-grade inflammation. At the cellular level, aging translates into telomeres shortening. Intriguingly, inflammation and telomere shortening show a bidirectional association: a pro-inflammatory state seems to contribute to aging and telomere dysfunction, and telomere attrition is able to induce low-grade inflammation. Several independent studies have reported shorter telomere length and increased levels of circulating inflammatory cytokines in mood disorders, suggesting a complex interplay between altered inflammatory-immune responses and telomere dynamics in the etiopathogenesis of these disorders. In this review, we critically discuss studies investigating the role of telomere attrition and inflammation in the pathogenesis and course of mood disorders, and in pharmacological treatments with psychotropic medications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- telomere shortening
- inflammation
- aging
- bipolar disorder
- major depression
- mood disorders
- lithium
- antidepressants
- mood stabilizers
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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