The anti-inflammatory potential of Portulaca oleracea L. (purslane) extract by partial suppression on NF-kappa B and MAPK activation

Miao, LingchaoUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China (författare)

Portulaca oleracea L. (Purslane) has great potential as food and traditional drugs in several countries. The purpose of this study was to evaluate the anti-inflammatory effects of purslane extract on lipopolysaccharide (LPS)stimulated RAW 264.7 cells. Purslane extracts significantly reduced LPS-induced synthesis of NO in a dose-dependent manner, as well as the expression levels of iNOS and COX-2. The productions of TNF-alpha and IL-6 were also significantly reduced at the higher dose of 400 mu g/ml. Meanwhile, the expression levels of P65, p-P65, p-MEK and p-I kappa B-alpha were inhibited dose-dependently. The nuclear translocation of P65 was partially prevented by the extract, which explained the inhibition of NF-kappa B pathway. In addition, three reported flavonoids, named luteolin, kaempferol and quercitrin, were identified in the extract, which might be responsible for its anti-inflammatory effects. Above all, our research has partially proved that purslane could be considered as a natural anti-inflammatory agent in further applications.

Tao, HongxunUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China (författare)
Peng, YuUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China (författare)
Wang, ShengpengUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China (författare)
Zhong, ZhangfengUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China (författare)
El-Seedi, HeshamUppsala universitet,Farmakognosi(Swepub:uu)heels173 (författare)
Dragan, SimonaUniv Med & Farm Timisoara, 2 Eftimie Murgu Sq, Timisoara 300041, Romania (författare)
Zengin, GokhanSelcuk Univ, Sci Fac, Dept Biol, Konya, Turkey (författare)
Cheang, Wai SanUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China (författare)
Wang, YitaoUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China (författare)
Xiao, JianboUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China (författare)
Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R ChinaFarmakognosi (creator_code:org_t)

Av författaren/redakt...: Miao, Lingchao; Tao, Hongxun; Peng, Yu; Wang, Shengpeng; Zhong, Zhangfeng; El-Seedi, Hesham; visa fler...; Dragan, Simona; Zengin, Gokhan; Cheang, Wai San; Wang, Yitao; Xiao, Jianbo; visa färre...

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