Sökning: onr:"swepub:oai:DiVA.org:uu-388700" >
Pregnancy and neona...
Pregnancy and neonatal complications in women with polycystic ovary syndrome in relation to second-trimester anti-Müllerian hormone levels
-
- Valdimarsdottir, Ragnheidur (författare)
- Uppsala universitet,Reproduktiv hälsa
-
- Valgeirsdóttir, Heiddis (författare)
- Uppsala universitet,Klinisk obstetrik
-
- Wikström, Anna-Karin, 1965- (författare)
- Karolinska Institutet,Uppsala universitet,Klinisk obstetrik
-
visa fler...
-
- Kallak, Theodora Kunovac, 1985- (författare)
- Uppsala universitet,Reproduktiv hälsa
-
- Elenis, Evangelia, 1983- (författare)
- Uppsala universitet,Reproduktiv hälsa
-
- Axelsson, Ove, 1944- (författare)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Obstetrisk och reproduktiv hälsoforskning
-
- Ubhayasekera, Kumari (författare)
- Uppsala universitet,Analytisk kemi
-
- Bergquist, Jonas (författare)
- Uppsala universitet,Analytisk kemi
-
- Piltonen, Terhi T (författare)
- Department of Obstetrics and Gynaecology, University of Oulu and Oulu University Hospital, Medical Research Center, PEDEGO Research Unit Oulu, Finland
-
- Pigny, Pascal (författare)
- Laboratoire de Biochimie & Hormonologie, Centre de Biologie Pathologie, Centre Hospitalier Régional Universitaire, CHU de Lille, Lille, France;Jean-Pierre Aubert Research Center (JPArc), Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, UMR-S 1172 Lille, France
-
- Giacobini, Paolo (författare)
- Jean-Pierre Aubert Research Center (JPArc), Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, UMR-S 1172 Lille, France;University of Lille, FHU 1,000 Days for Health, School of Medicine Lille, France
-
- Sundström Poromaa, Inger, 1964- (författare)
- Uppsala universitet,Reproduktiv hälsa
-
visa färre...
-
(creator_code:org_t)
- Elsevier, 2019
- 2019
- Engelska.
-
Ingår i: Reproductive BioMedicine Online. - : Elsevier. - 1472-6483 .- 1472-6491. ; 39:1, s. 141-148
- Relaterad länk:
-
http://jultika.oulu....
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Research Question: An association has been found between high anti-Müllerian hormone (AMH) levels during pregnancy and the development of polycystic ovary syndrome (PCOS)-like phenotypic traits in mouse offspring. The aim of this study was to determine whether AMH levels are associated with maternal testosterone levels, and whether high AMH concentration influences the risk of developing PCOS-related adverse pregnancy outcomes.Design: Maternal serum AMH, testosterone and sex hormone binding globulin levels were measured in blood samples taken in early second-trimester pregnancies from women with PCOS (n = 159) and healthy controls matched for body mass index (n = 320). Possible associations with preeclampsia, gestational hypertension, gestational diabetes, preterm birth and birthweight was explored by logistic and linear regression models.Results: Women with PCOS had higher AMH, higher total testosterone levels and higher free androgen index than controls (P < 0.001 for all three parameters). Among women with PCOS, high testosterone levels (B = 2.7; β = 0.26; P = 0.001) and low first trimester body mass index (B = -0.5; β = -0.17; P = 0.043) remained independently associated with AMH. High AMH levels were associated with decreased risk of gestational hypertension (adjusted OR 0.55; 95% CI 0.34 to 0.87), but no association was found with other adverse pregnancy outcomes or birthweight.Conclusions: Women with PCOS had higher AMH levels during pregnancy compared with controls, but high AMH was not associated with increased risk of adverse pregnancy outcomes or birthweight.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Birthweight
- Polycystic ovary syndrome
- anti-Müllerian hormone
- Pregnancy complications
- Testosterone
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Valdimarsdottir, ...
-
Valgeirsdóttir, ...
-
Wikström, Anna-K ...
-
Kallak, Theodora ...
-
Elenis, Evangeli ...
-
Axelsson, Ove, 1 ...
-
visa fler...
-
Ubhayasekera, Ku ...
-
Bergquist, Jonas
-
Piltonen, Terhi ...
-
Pigny, Pascal
-
Giacobini, Paolo
-
Sundström Poroma ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reproduktionsmed ...
- Artiklar i publikationen
-
Reproductive Bio ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet