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Idiopathic short st...
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Derraik, Jose G. B.Uppsala universitet,Institutionen för kvinnors och barns hälsa,Univ Auckland, Liggins Inst, Auckland, New Zealand;Univ Auckland, Better Start Natl Sci Challenge, Auckland, New Zealand
(författare)
Idiopathic short stature and growth hormone sensitivity in prepubertal children
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-04-10
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Wiley,2019
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-388758
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-388758URI
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https://doi.org/10.1111/cen.13976DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Objective: We compared growth hormone sensitivity to an insulin-like growth factor I (IGF-I) generation test in children with idiopathic short stature (ISS) and of normal stature (NS) across the birthweight range.Methods: Forty-six prepubertal children (~7.1 years) born at term were studied: ISS (n = 23; 74% boys) and NS (n = 23; 57% boys). Children underwent a modified IGF-I generation test with recombinant human growth hormone (rhGH; 0.05 mg/kg/d) over four consecutive days. Hormonal concentrations were measured at baseline and day 5.Results: Children with idiopathic short stature were 1.90 SDS lighter (P < 0.0001) but had 4.5% more body fat (P = 0.0007) than NS children. Overall, decreasing birthweight SDS across the normal range (-1.9 to +1.5 SDS) was associated with lower percentage IGF-I response to rhGH stimulation in univariable (r = 0.45; P = 0.002) and multivariable models (β = 24.6; P = 0.006). Plasma IGF-I concentrations rose in both groups with rhGH stimulation (P < 0.0001). GHBP levels (P = 0.002) were suppressed in ISS children (-19%; P = 0.029) but increased among NS children (+18%; P = 0.028), with contrasting responses also observed for leptin and IGFBP-1. Further, the increase in insulin concentrations in response to rhGH stimulation was ~3-fold greater in NS children (142% vs 50%; P = 0.006).Conclusions: A progressive decrease in birthweight SDS was associated with a reduction in GH sensitivity in both NS and ISS children. Thus, the lower IGF-I response to rhGH stimulation in association with decreasing birthweight indicates that the ISS children at the lower end of the birthweight spectrum may have partial GH resistance, which may contribute to their poorer growth.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Miles, Harriet L.Univ Auckland, Liggins Inst, Auckland, New Zealand
(författare)
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Chiavaroli, ValentinaUniv Auckland, Liggins Inst, Auckland, New Zealand
(författare)
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Hofman, Paul L.Univ Auckland, Liggins Inst, Auckland, New Zealand
(författare)
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Cutfield, Wayne S.Univ Auckland, Liggins Inst, Auckland, New Zealand;Univ Auckland, Better Start Natl Sci Challenge, Auckland, New Zealand
(författare)
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Uppsala universitetInstitutionen för kvinnors och barns hälsa
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinical Endocrinology: Wiley91:1, s. 110-1170300-06641365-2265
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