Reference Intervals for Fecal Calprotectin in Pregnant Women Using a Particle Enhanced Turbidimetric Assay

Fall, Tove,1979-Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab (författare)

BACKGROUND: Fecal calprotectin is widely used as a marker for inflammatory bowel diseases (IBD). IBD often affects women during their reproductive years, but there are no established reference intervals during pregnancy. The aim of the present study was to define reference values during pregnancy and in the postpartum period to allow comparisons between patient results and reference values.METHODS: Fecal samples were collected from 84 healthy females during pregnancy week 26 to 28 and a second sample was collected six months after delivery. The samples were weighed, extracted, and centrifugated to remove debris. The extracted samples were then analyzed on a chemistry analyzer using a particle enhanced turbidimetric immunoassay reagent.RESULTS: The calculated reference interval during pregnancy was < 127 μg/g (90% confidence interval, 90 - 164 μg/g) and the corresponding reference interval during the postpartum period was < 143 μg/g (60 - 226 μg/g). There were no significant statistical differences between F-calprotectin values analyzed at the two sampling times.CONCLUSIONS: The reference values are slightly higher than the cutoff values of 50 - 100 μg/g often used as General cutoff for fecal calprotectin.

Hedman, AnnaKarolinska Institutet (författare)
Pershagen, GöranKarolinska Institutet (författare)
Andolf, EllikaKarolinska Institutet (författare)
Almqvist, CatarinaKarolinska Institutet (författare)
Helmersson-Karlqvist, JohannaUppsala universitet,Klinisk kemi(Swepub:uu)johahelm (författare)
Larsson, AndersUppsala universitet,Klinisk kemi(Swepub:uu)andlarss (författare)
Uppsala universitetMolekylär epidemiologi (creator_code:org_t)

Av författaren/redakt...: Fall, Tove, 1979 ...; Hedman, Anna; Pershagen, Göran; Andolf, Ellika; Almqvist, Catari ...; Helmersson-Karlq ...; visa fler...; Larsson, Anders; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Klinisk laborato ...

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