Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Prasad, BhagwatUniv Washington, Dept Pharmaceut, Seattle, WA 98195 USA (författare)

Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research : A White Paper

Quantitative translation of information on drug absorption, disposition, receptor engagement, and drug-drug interactions from bench to bedside requires models informed by physiological parameters that link in vitro studies to in vivo outcomes. To predict in vivo outcomes, biochemical data from experimental systems are routinely scaled using protein quantity in these systems and relevant tissues. Although several laboratories have generated useful quantitative proteomic data using state-of-the-art mass spectrometry, no harmonized guidelines exit for sample analysis and data integration to in vivo translation practices. To address this gap, a workshop was held on September 27 and 28, 2018, in Cambridge, MA, with 100 experts attending from academia, the pharmaceutical industry, and regulators. Various aspects of quantitative proteomics and its applications in translational pharmacology were debated. A summary of discussions and best practices identified by this expert panel are presented in this "White Paper" alongside unresolved issues that were outlined for future debates.

Achour, BrahimUniv Manchester, Ctr Appl Pharmacokinet Res, Manchester, Lancs, England (författare)
Artursson, PerUppsala universitet,Institutionen för farmaci(Swepub:uu)perartur (författare)
Hop, Cornelis E. C. A.Genentech Inc, San Francisco, CA USA (författare)
Lai, YurongGilead Sci, Foster City, CA USA (författare)
Smith, Philip C.Univ N Carolina, Eshelman Sch Pharm, Chapel Hill, NC 27515 USA (författare)
Barber, JillUniv Manchester, Ctr Appl Pharmacokinet Res, Manchester, Lancs, England (författare)
Wisniewski, Jacek R.Max Planck Inst Biochem, Biochem Prote Grp, Martinsried, Germany (författare)
Spellman, DanielMerck & Co Inc, Pharmacokinet Pharmacodynam & Drug Metab, West Point, PA USA (författare)
Uchida, YasuoTohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi, Japan (författare)
Zientek, Michael A.Takeda Calif, San Diego, CA USA (författare)
Unadkat, Jashvant D.Univ Washington, Dept Pharmaceut, Seattle, WA 98195 USA (författare)
Rostami-Hodjegan, AminUniv Manchester, Ctr Appl Pharmacokinet Res, Manchester, Lancs, England;Certara Simcyp Div, Sheffield, S Yorkshire, England (författare)
Univ Washington, Dept Pharmaceut, Seattle, WA 98195 USAUniv Manchester, Ctr Appl Pharmacokinet Res, Manchester, Lancs, England (creator_code:org_t)

Ingår i:Clinical Pharmacology and Therapeutics: WILEY106:3, s. 525-5430009-92361532-6535

Av författaren/redakt...: Prasad, Bhagwat; Achour, Brahim; Artursson, Per; Hop, Cornelis E. ...; Lai, Yurong; Smith, Philip C.; visa fler...; Barber, Jill; Wisniewski, Jace ...; Spellman, Daniel; Uchida, Yasuo; Zientek, Michael ...; Unadkat, Jashvan ...; Rostami-Hodjegan ...; visa färre...

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