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Dietary flavonoids ...
Dietary flavonoids with a catechol structure increase alpha-tocopherol in rats and protect the vitamin from oxidation in vitro
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Frank, J. (författare)
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Budek, A. (författare)
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Lundh, T. (författare)
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Parker, R.S. (författare)
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Swanson, J.E. (författare)
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Lourenco, C.F. (författare)
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Gago, B. (författare)
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Laranjinha, J. (författare)
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- Vessby, Bengt (författare)
- Uppsala universitet,Geriatrik
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Kamal-Eldin, A. (författare)
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(creator_code:org_t)
- 2006
- 2006
- Engelska.
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Ingår i: Journal of Lipid Research. - 0022-2275 .- 1539-7262. ; 47:12, s. 2718-2725
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- To identify dietary phenolic compounds capable of improving vitamin E status, male Sprague-Dawleyrats were fed for 4 weeks either a basal diet ( control) with 2 g/kg cholesterol and an adequate content of vitamin E or the basal diet fortified with quercetin ( Q), (2)-epicatechin (EC), or (1)-catechin ( C) at concentrations of 2 g/kg. All three catechol derivatives substantially increased concentrations of alpha-tocopherol (alpha-T) in blood plasma and liver. To study potential mechanisms underlying the observed increase of alpha-T, the capacities of the Flavonoids to i) protect alpha-T from oxidation in LDL exposed to peroxyl radicals, ii) reduce alpha-tocopheroxyl radicals (alpha-T-.) in SDS micelles, and iii) inhibit the metabolism of tocopherols in HepG2 cells were determined. All flavonoids protected alpha-T from oxidation in human LDL ex vivo and dose-dependently reduced the concentrations of alpha-T-.. None of the test compounds affected vitamin E metabolism in the hepatocyte cultures. In conclusion, fortification of the diet of Sprague-Dawley rats with Q, EC, or C considerably improved their vitamin E status. The underlying mechanism does not appear to involve vitamin E metabolism but may involve direct quenching of free radicals or reduction of the alpha-T-. by the flavonoids.
Nyckelord
- (+)-catechin
- cytochrome P-450
- (-)-epicatechin
- hepatocytes
- HepG2
- quercetin
- tocopherol-omega-hydroxylase
- tocopheroxyl radical
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Frank, J.
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Budek, A.
-
Lundh, T.
-
Parker, R.S.
-
Swanson, J.E.
-
Lourenco, C.F.
-
visa fler...
-
Gago, B.
-
Laranjinha, J.
-
Vessby, Bengt
-
Kamal-Eldin, A.
-
visa färre...
- Artiklar i publikationen
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Journal of Lipid ...
- Av lärosätet
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Uppsala universitet