Sökning: onr:"swepub:oai:DiVA.org:uu-400949" > Prognostic impact o...
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000 | 03874naa a2200481 4500 | |
001 | oai:DiVA.org:uu-400949 | |
003 | SwePub | |
008 | 200103s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4009492 URI |
024 | 7 | a https://doi.org/10.1111/ejh.133612 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Abdulla, Maysaau Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini4 aut0 (Swepub:uu)mayab806 |
245 | 1 0 | a Prognostic impact of abdominal lymph node involvement in diffuse large B-cell lymphoma |
264 | c 2019-12-20 | |
264 | 1 | b Wiley,c 2020 |
338 | a electronic2 rdacarrier | |
520 | a OBJECTIVE: The prognostic value of site of nodal involvement in diffuse large B-cell lymphomas (DLBCL) is mainly unknown. We aimed to determine the prognostic significance of nodal abdominal involvement in relation to tumour cell markers and clinical characteristics of 249 DLBCL patients in a retrospective single-centre study.METHODS: Contrast-enhanced computed tomography (CT) of the abdomen and thorax revealed pathologically enlarged abdominal lymph nodes in 156 patients, while in 93 patients there were no pathologically enlarged lymph nodes in the abdomen. In 81 cases, the diagnosis of DLBCL was verified by histopathological biopsy obtained from abdominal lymph node.RESULTS: Patients with abdominal nodal disease had inferior lymphoma-specific survival (P = .04) and presented with higher age-adjusted IPI (P < .001), lactate dehydrogenase (P < .001) and more often advanced stage (P < .001), bulky disease (P < .001), B symptoms (P < .001), and double expression of MYC and BCL2 (P = .02) compared to patients without nodal abdominal involvement, but less often extranodal involvement (P < .02). The worst outcome was observed in those where the abdominal nodal involvement was verified by histopathological biopsy.CONCLUSION: Diffuse large B-cell lymphomas patients with abdominal nodal disease had inferior outcome and more aggressive behaviour, reflected both in clinical and biological characteristics. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
653 | a BCL2 | |
653 | a DLBCL | |
653 | a MYC | |
653 | a abdominal lymph node | |
653 | a survival | |
653 | a Patologi | |
653 | a Pathology | |
700 | 1 | a Guglielmo, Priscillau Uppsala universitet,Radiologi,Brotzu General Hospital, Cagliari, Italy4 aut |
700 | 1 | a Hollander, Peteru Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini4 aut0 (Swepub:uu)petho189 |
700 | 1 | a Åström, Gunnar,d 1955-u Uppsala universitet,Radiologi4 aut0 (Swepub:uu)gunnaras |
700 | 1 | a Ahlström, Håkan,d 1953-u Uppsala universitet,Radiologi4 aut0 (Swepub:uu)hakanahl |
700 | 1 | a Enblad, Gunillau Uppsala universitet,Experimentell och klinisk onkologi4 aut0 (Swepub:uu)gunienbl |
700 | 1 | a Amini, Rose-Marieu Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini4 aut0 (Swepub:uu)roseamin |
710 | 2 | a Uppsala universitetb Klinisk och experimentell patologi4 org |
773 | 0 | t European Journal of Haematologyd : Wileyg 104:3, s. 207-213q 104:3<207-213x 0902-4441x 1600-0609 |
856 | 4 | u https://doi.org/10.1111/ejh.13361y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1382649/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejh.13361 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-400949 |
856 | 4 8 | u https://doi.org/10.1111/ejh.13361 |
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