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Effects of 1-year a...
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Gulyas, KatalinUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary;Dept Sports Med, Debrecen, Debrecen, Hungary
(författare)
Effects of 1-year anti-TNF-α therapies on bone mineral density and bone biomarkers in rheumatoid arthritis and ankylosing spondylitis
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2019-09-14
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Springer Science and Business Media LLC,2020
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-407442
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-407442URI
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https://doi.org/10.1007/s10067-019-04771-3DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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ObjectivesRheumatoid arthritis (RA) and ankylosing spondylitis (AS) have been associated with generalized and localized bone loss. We conducted a comprehensive study using imaging (dual-energy X-ray absorptiometry, DXA) and laboratory biomarkers in order to determine bone health and to study the effects of anti-tumor necrosis factor (TNF) biologics in RA and AS.Patients and methodsThirty-six RA and 17 AS patients undergoing 1-year etanercept (ETN) or certolizumab-pegol (CZP) therapy were studied. Bone density was assessed by DXA at baseline and after 12 months. Serum C-reactive protein (CRP), calcium, phosphate, parathyroid hormone (PTH), vitamin D3, osteocalcin, procollagen type I N-propeptide (P1NP), C-terminal telopeptide (βCTX), osteoprotegerin, sclerostin (SOST), Dickkopf-1 (DKK-1), soluble receptor activator nuclear kappa B ligand (sRANKL), and cathepsin K (cathK) levels were determined at baseline and after 6 and 12 months.ResultsTNF-α inhibition was clinically effective. Anti-TNF-α halted further bone loss over 1 year. In general, anti-TNF therapy significantly increased P1NP, SOST levels, and the P1NP/βCTX ratios, while decreased DKK-1 and CathK production at different time points in most patient subsets. In the full cohort and in RA, baseline and/or 12-month bone mineral density (BMD) at multiple sites exerted inverse relationships with CRP and βCTX, and positive correlation with SOST. In AS, L2-4 BMD after 1-year biologic therapy inversely correlated with baseline βCTX, while femoral neck BMD rather showed inverse correlations with CRP.ConclusionsAnti-TNF therapy slowed down generalized bone loss, in association with clinical improvements, in both diseases. TNF blockade may enhance bone formation and suppress joint destruction. Anti-TNF therapy may act inversely on DKK-1 and SOST. Independent predictors of BMD were SOST and βCTX in RA, whilst CRP in AS.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Horvath, AgnesUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
(författare)
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Vegh, EditUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
(författare)
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Pusztai, AnitaUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
(författare)
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Szentpetery, AgnesUppsala universitet,Reumatologi,Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary;Vincent's Univ Hosp, Univ Coll Dublin, Conway Inst BioMol Res, Dept Rheumatol, St, Dublin, Ireland
(författare)
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Petho, ZsofiaUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
(författare)
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Vancsa, AndreaUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
(författare)
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Bodnar, NoraUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
(författare)
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Csomor, PeterUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
(författare)
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Hamar, AttilaUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
(författare)
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Bodoki, LeventeUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
(författare)
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Bhattoa, Harjit PalUniv Debrecen, Fac Med, Dept Lab Med, Debrecen, Debrecen, Hungary
(författare)
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Juhasz, BalazsUniv Debrecen, Fac Med, Dept Oncology, Debrecen, Debrecen, Hungary
(författare)
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Nagy, ZoltanUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
(författare)
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Hodosi, KatalinUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
(författare)
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Karosi, TamasBorsod Cty Teaching Hosp, Dept Otolaryngology, Miskolc, Miskolc, Hungary
(författare)
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FitzGerald, OliverVincent's Univ Hosp, Univ Coll Dublin, Conway Inst BioMol Res, Dept Rheumatol, St, Dublin, Ireland
(författare)
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Szucs, GabriellaUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
(författare)
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Szekanecz, ZoltanUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
(författare)
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Szamosi, SzilviaUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
(författare)
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Szanto, SandorUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary;Dept Sports Med, Debrecen, Debrecen, Hungary
(författare)
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Univ Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary;Dept Sports Med, Debrecen, Debrecen, HungaryUniv Debrecen, Fac Med, Dept Internal Med, Div Rheumatol, Nagyerde str 98, H-4032 Debrecen, Debrecen, Hungary
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinical Rheumatology: Springer Science and Business Media LLC39:1, s. 167-1750770-31981434-9949
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Till lärosätets databas
- Av författaren/redakt...
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Gulyas, Katalin
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Horvath, Agnes
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Vegh, Edit
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Pusztai, Anita
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Szentpetery, Agn ...
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Petho, Zsofia
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visa fler...
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Vancsa, Andrea
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Bodnar, Nora
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Csomor, Peter
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Hamar, Attila
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Bodoki, Levente
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Bhattoa, Harjit ...
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Juhasz, Balazs
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Nagy, Zoltan
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Hodosi, Katalin
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Karosi, Tamas
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FitzGerald, Oliv ...
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Szucs, Gabriella
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Szekanecz, Zolta ...
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Szamosi, Szilvia
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Szanto, Sandor
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visa färre...
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