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The effect of food ...
The effect of food on the pharmacokinetics of oral ivermectin
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- Duthaler, Urs (författare)
- Univ & Univ Hosp Basel, Dept Biomed, Div Clin Pharmacol & Toxicol, Basel, Switzerland
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- Leisegang, Rory (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Karlsson, Mats (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Krähenbühl, Stephan (författare)
- Univ & Univ Hosp Basel, Dept Biomed, Div Clin Pharmacol & Toxicol, Basel, Switzerland
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- Hammann, Felix (författare)
- Univ & Univ Hosp Basel, Dept Biomed, Div Clin Pharmacol & Toxicol, Basel, Switzerland;Univ Bern, Bern Univ Hosp, Dept Gen Internal Med, Inselspital,Clin Pharmacol & Toxicol, Bern, Switzerland;Univ Bern, Inst Pharmacol, Bern, Switzerland
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(creator_code:org_t)
- 2019-11-06
- 2020
- Engelska.
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Ingår i: Journal of Antimicrobial Chemotherapy. - : OXFORD UNIV PRESS. - 0305-7453 .- 1460-2091. ; 75:2, s. 438-440
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Ivermectin is an older anthelminthic agent that is being studied more intensely given its potential for mass drug administration against scabies, malaria and other neglected tropical diseases. Its pharmacokinetics (PK) remain poorly characterized. Furthermore, the majority of PK trials are performed under fasted-state dosing conditions, and the effect of food is therefore not well known. To better plan and design field trials with ivermectin, a model that can account for both conditions would be valuable.Objectives: To develop a PK model and characterize the food effect with single oral doses of ivermectin.Patients and methods: We performed a population-based PK analysis of data pooled from two previous trials of a single dose of 12mg ivermectin, one with dosing after a high-fat breakfast (n=12) and one with fasted-state dosing (n=3).Results: The final model described concentration-time profiles after fed and fasted dosing accurately, and estimated the food effect associated with relative bioavailability to 1.18 (95% CI 1.10-1.67).Conclusions: In this analysis, the effect of a high-fat breakfast compared with a fasted-state administration of a single oral dose of 12mg ivermectin was minimal.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
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