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Sökning: onr:"swepub:oai:DiVA.org:uu-419027" > Ovarian cancer risk...

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FältnamnIndikatorerMetadata
00006281naa a2201093 4500
001oai:DiVA.org:uu-419027
003SwePub
008200908s2019 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-159048
009oai:prod.swepub.kib.ki.se:140827619
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4190272 URI
0247 a https://doi.org/10.1002/ijc.320752 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1590482 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1408276192 URI
040 a (SwePub)uud (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Fortner, Renée T.4 aut
2451 0a Ovarian cancer risk factors by tumor aggressiveness :b An analysis from the Ovarian Cancer Cohort Consortium
264 c 2019-01-14
264 1b Wiley,c 2019
338 a print2 rdacarrier
520 a Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in <1 year, n = 864), very aggressive (death in 1 to < 3 years, n = 1,390), moderately aggressive (death in 3 to < 5 years, n = 639), and less aggressive (lived 5+ years, n = 1,691). Using competing risks Cox proportional hazards regression, we assessed heterogeneity of associations by tumor aggressiveness for all cases and among serous and endometrioid/clear cell tumors. Associations between parity (phet = 0.01), family history of ovarian cancer (phet = 0.02), body mass index (BMI; phet ≤ 0.04) and smoking (phet < 0.01) and ovarian cancer risk differed by aggressiveness. A first/single pregnancy, relative to nulliparity, was inversely associated with highly aggressive disease (HR: 0.72; 95% CI [0.58-0.88]), no association was observed for subsequent pregnancies (per pregnancy, 0.97 [0.92-1.02]). In contrast, first and subsequent pregnancies were similarly associated with less aggressive disease (0.87 for both). Family history of ovarian cancer was only associated with risk of less aggressive disease (1.94 [1.47-2.55]). High BMI (≥35 vs. 20 to < 25 kg/m2 , 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a aggressiveness
653 a ovarian cancer
653 a prospective cohort
653 a risk factors
653 a subtypes
7001 a Poole, Elizabeth M.4 aut
7001 a Wentzensen, Nicolas A.4 aut
7001 a Trabert, Britton4 aut
7001 a White, Emily4 aut
7001 a Arslan, Alan A.4 aut
7001 a Patel, Alpa V.4 aut
7001 a Setiawan, V. Wendy4 aut
7001 a Visvanathan, Kala4 aut
7001 a Weiderpass, Elisabeteu Karolinska Institutet4 aut
7001 a Adami, Hans-Olovu Karolinska Institutet4 aut
7001 a Black, Amanda4 aut
7001 a Bernstein, Leslie4 aut
7001 a Brinton, Louise A.4 aut
7001 a Buring, Julie4 aut
7001 a Clendenen, Tess V.4 aut
7001 a Fournier, Agnès4 aut
7001 a Fraser, Gary4 aut
7001 a Gapstur, Susan M.4 aut
7001 a Gaudet, Mia M.4 aut
7001 a Giles, Graham G.4 aut
7001 a Gram, Inger T.4 aut
7001 a Hartge, Patricia4 aut
7001 a Hoffman-Bolton, Judith4 aut
7001 a Idahl, Annika,d 1965-u Umeå universitet,Obstetrik och gynekologi4 aut0 (Swepub:umu)anid0002
7001 a Kaaks, Rudolf4 aut
7001 a Kirsh, Victoria A.4 aut
7001 a Knutsen, Synnove4 aut
7001 a Koh, Woon-Puay4 aut
7001 a Lacey, James V.4 aut
7001 a Lee, I-Min4 aut
7001 a Lundin, Evau Umeå universitet,Patologi4 aut0 (Swepub:umu)evlu0001
7001 a Merritt, Melissa A.4 aut
7001 a Milne, Roger L.4 aut
7001 a Onland-Moret, N. Charlotte4 aut
7001 a Peters, Ulrike4 aut
7001 a Poynter, Jenny N.4 aut
7001 a Rinaldi, Sabina4 aut
7001 a Robien, Kim4 aut
7001 a Rohan, Thomas4 aut
7001 a Sánchez, Maria-José4 aut
7001 a Schairer, Catherine4 aut
7001 a Schouten, Leo J.4 aut
7001 a Tjonneland, Anne4 aut
7001 a Townsend, Mary K.4 aut
7001 a Travis, Ruth C.4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a van den Brandt, Piet A.4 aut
7001 a Vineis, Paolo4 aut
7001 a Wilkens, Lynne4 aut
7001 a Wolk, Alicjau Karolinska Institutet4 aut
7001 a Yang, Hannah P.4 aut
7001 a Zeleniuch-Jacquotte, Anne4 aut
7001 a Tworoger, Shelley S.4 aut
7102 a Karolinska Institutetb Obstetrik och gynekologi4 org
7730 t International Journal of Cancerd : Wileyg 145:1, s. 58-69q 145:1<58-69x 0020-7136x 1097-0215
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.32075
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419027
8564 8u https://doi.org/10.1002/ijc.32075
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-159048
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:140827619

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