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Dietary exposure to...
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Donat-Vargas, CarolinaKarolinska Institutet
(författare)
Dietary exposure to polychlorinated biphenyls and risk of breast, endometrial and ovarian cancer in a prospective cohort
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2016-09-15
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NATURE PUBLISHING GROUP,2016
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-419408
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419408URI
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https://doi.org/10.1038/bjc.2016.282DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:134485221URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Background: Observational studies on polychlorinated biphenyl (PCB) exposure and hormone-related cancer risk are either inconsistent or lacking. We aimed to assess associations of dietary PCB exposure with breast, endometrial and ovarian cancer risk in middle-aged and elderly women. Methods: We included 36 777 cancer-free women at baseline in 1997 from the prospective population-based Swedish Mammography Cohort. Validated estimates of dietary PCB exposure were obtained via a food frequency questionnaire. Incident cancer cases were ascertained through register linkage. Results: During 14 years of follow-up, we ascertained 1593, 437 and 195 incident cases of breast, endometrial and ovarian cancer. We found no overall association between dietary PCB exposure and any of these cancer forms. The multivariable-adjusted relative risks comparing women in the highest and lowest tertile of PCB exposure were 0.96 (95% confidence interval (CI): 0.75, 1.24), 1.21 (95% CI: 0.73, 2.01) and 0.90 (95% CI: 0.45, 1.79) for breast, endometrial and ovarian cancer. In analyses stratified by factors influencing oestrogen exposure, possibly masking associations with PCBs, indications of higher risks were observed for endometrial cancer. Conclusions: This study suggests that dietary exposure to PCBs play no critical role in the development of breast, endometrial or ovarian cancer during middle-age and old ages.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Akesson, AgnetaKarolinska Institutet
(författare)
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Berglund, MarikaKarolinska Institutet
(författare)
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Glynn, AndersNatl Food Agcy, Dept Risk & Benefit Assessment, Box 622, SE-75126 Uppsala, Sweden.
(författare)
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Wolk, AlicjaKarolinska Inst, Inst Environm Med, Box 210, SE-17177 Stockholm, Sweden.
(författare)
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Kippler, MariaKarolinska Institutet
(författare)
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Karolinska InstitutetNatl Food Agcy, Dept Risk & Benefit Assessment, Box 622, SE-75126 Uppsala, Sweden.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Cancer: NATURE PUBLISHING GROUP115:9, s. 1113-11210007-09201532-1827
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