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Seizures during tre...
Seizures during treatment of childhood acute lymphoblastic leukemia : A population-based cohort study
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- Anastasopoulou, Stavroula (författare)
- Karolinska Institutet
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- Heyman, Mats (författare)
- Karolinska Institutet
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- Eriksson, Mats A. (författare)
- Karolinska Institutet
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- Niinimaki, Riitta (författare)
- Oulu Univ Hosp, Dept Children & Adolescents, Oulu, Finland.;Univ Oulu, PEDEGO Res Unit, Oulu, Finland.
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- Taskinen, Mervi (författare)
- Helsinki Univ Hosp, Div Pediat Hematol & Oncol & Stem Cell Transplant, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
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- Mikkel, Sirje (författare)
- Univ Tartu, Dept Hematol & Oncol, Tartu, Estonia.
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- Vaitkeviciene, Goda E. (författare)
- Vilnius Univ Hosp Santaros Klin, Childrens Hosp, Vilnius, Lithuania.;Vilnius Univ, Vilnius, Lithuania.
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- Johannsdottir, Inga Maria (författare)
- Oslo Univ Hosp, Dept Pediat Hematol Oncol, Oslo, Norway.
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- Myrberg, Ida Hed (författare)
- Karolinska Institutet
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- Jonsson, Olafur Gisli (författare)
- Univ Iceland, Dept Pediat, Reykjavik, Iceland.
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- Als-Nielsen, Bodil (författare)
- Univ Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark.
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- Schmiegelow, Kjeld (författare)
- Univ Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Fac Med, Inst Clin Med, Copenhagen, Denmark.
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- Banerjee, Joanna (författare)
- Helsinki Univ Hosp, Div Pediat Hematol & Oncol & Stem Cell Transplant, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
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- Ranta, Susanna (författare)
- Karolinska Institutet
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- Harila-Saari, Arja H. (författare)
- Uppsala universitet,Barnneurologi/Barnonkologi
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Karolinska Institutet Oulu Univ Hosp, Dept Children & Adolescents, Oulu, Finland;Univ Oulu, PEDEGO Res Unit, Oulu, Finland. (creator_code:org_t)
- ELSEVIER SCI LTD, 2020
- 2020
- Engelska.
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Ingår i: European journal of paediatric neurology. - : ELSEVIER SCI LTD. - 1090-3798 .- 1532-2130. ; 27, s. 72-77
- Relaterad länk:
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https://helda.helsin...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Seizures are common in children with acute lymphoblastic leukemia (ALL). As ALL survival rates are improving, the challenge to minimize treatment related side effects and late sequelae rises. Here, we studied the frequency, timing, etiology and risk factors of seizures in ALL patients. Methods: The study included children aged 1-17.9 years at diagnosis of B-cell-precursor and T cell ALL who were treated according to the Nordic Society of Pediatric Hematology and Oncology (NOPHO) ALL2008 protocol between 2008 and 2015. Detailed patient data were acquired from the NOPHO ALL2008 registry and by review of medical records. Results: Seizures occurred in 81/1464 (5.5%) patients. The cumulative incidence of seizures at one months was 1.7% (95% CI: 1.2-2.5) and at one year 5.3% (95% CI 4.2-6.5%). Patients aged 10-17.9 years, those with T cell immunophenotype, CNS involvement, or high-risk induction with dexamethasone had higher risk for seizures in univariable analyses. Only age remained a risk factor in multivariable analyses (the cumulative incidence of seizures for patients 10-17.9 years old at one year was 9.0% (95% CI: 6.2-12.9)). Of the 81 patients with seizures, 43 had posterior reversible encephalopathy syndrome (PRES), 15 had isolated seizures, nine had sinus venous thrombosis (SVT), three had stroke-like syndrome, and 11 had other neurotoxicities. Epilepsy diagnosis was reported in totally 11 ALL survivors at last follow up. Conclusion: Seizures are relatively common in ALL patients and occur most often in patients with PRES, SVT, or as an isolated symptom. Older children have higher risk of seizures. (C) 2020 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Epilepsy
- ALL
- Neurotoxicity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Anastasopoulou, ...
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Heyman, Mats
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Eriksson, Mats A ...
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Niinimaki, Riitt ...
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Taskinen, Mervi
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Mikkel, Sirje
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visa fler...
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Vaitkeviciene, G ...
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Johannsdottir, I ...
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Myrberg, Ida Hed
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Jonsson, Olafur ...
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Als-Nielsen, Bod ...
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Schmiegelow, Kje ...
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Banerjee, Joanna
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Ranta, Susanna
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Harila-Saari, Ar ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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European journal ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet