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Colistin plus merop...
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Nutman, AmirTel Aviv Med Ctr & Sch Med, Natl Inst Infect Control & Antibiot Resistance, Tel Aviv, Israel.;Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
(författare)
Colistin plus meropenem for carbapenem-resistant Gram-negative infections : in vitro synergism is not associated with better clinical outcomes
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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Elsevier BV,2020
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-420891
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-420891URI
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https://doi.org/10.1016/j.cmi.2020.03.035DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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ObjectivesIn vitro models showing synergism between polymyxins and carbapenems support combination treatment for carbapenem-resistant Gram-negative (CRGN) infections. We tested the association between the presence of in vitro synergism and clinical outcomes in patients treated with colistin plus meropenem.MethodsThis was a secondary analysis of AIDA, a randomized controlled trial comparing colistin with colistin–meropenem for severe CRGN infections. We tested in vitro synergism using a checkerboard assay. Based on the fractional inhibitory concentration (ΣFIC) index for each colistin–meropenem combination, we categorized results as synergistic, antagonistic or additive/indifferent. The primary outcome was clinical failure at 14 days. Secondary outcomes were 14- and 28-day mortality and microbiological failure.ResultsThe sample included 171 patients with infections caused by carbapenem-resistant Acinetobacter baumannii (n = 131), Enterobacteriaceae (n = 37) and Pseudomonas aeuruginosa (n = 3). In vitro testing showed synergism for 73 isolates, antagonism for 20 and additivism/indifference for 78. In patients who received any colistin plus meropenem, clinical failure at 14 days was 59/78 (75.6%) in the additivism/indifference group (reference category), 54/73 (74.0%) in the synergism group (adjusted odds ratio (aOR) 0.76, 95% CI 0.31–1.83), and 11/20 (55%) in the antagonism group (aOR 0.77, 95% CI 0.22–2.73). There was no significant difference between groups for any secondary outcome. Comparing the synergism group to patients treated with colistin monotherapy, synergism was not protective against 14-day clinical failure (aOR 0.52, 95% CI 0.26–1.04) or 14-day mortality (aOR1.09, 95% CI 0.60–1.96).DiscussionIn vitro synergism between colistin and meropenem via checkerboard method did not translate into clinical benefit.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lellouche, JonathanTel Aviv Med Ctr & Sch Med, Natl Inst Infect Control & Antibiot Resistance, Tel Aviv, Israel.
(författare)
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Temkin, ElizabethTel Aviv Med Ctr & Sch Med, Natl Inst Infect Control & Antibiot Resistance, Tel Aviv, Israel.
(författare)
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Daikos, GeorgeLaikon Gen Hosp, Dept Med 1, Athens, Greece.;Natl & Kapodistrian Univ Athens, Athens, Greece.
(författare)
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Skiada, AnnaLaikon Gen Hosp, Dept Med 1, Athens, Greece.;Natl & Kapodistrian Univ Athens, Athens, Greece.
(författare)
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Durante-Mangoni, EmanueleUniv Campania Luigi Vanvitelli, Dept Precis Med, Naples, Italy.;AORN Colli Monaldi Hosp, Naples, Italy.
(författare)
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Dishon-Benattar, YaelRambam Hlth Care Campus, Inst Infect Dis, Haifa, Israel.;Univ Haifa, Cheryl Spencer Inst Nursing Res, Haifa, Israel.
(författare)
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Bitterman, RoniRambam Hlth Care Campus, Inst Infect Dis, Haifa, Israel.
(författare)
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Yahav, DafnaTel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.;Beilinson Med Ctr, Rabin Med Ctr, Infect Dis Unit, Petah Tiqwa, Israel.
(författare)
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Daitch, VeredTel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.;Beilinson Med Ctr, Rabin Med Ctr, Infect Dis Unit, Petah Tiqwa, Israel.
(författare)
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Bernardo, MarianoUniv Campania Luigi Vanvitelli, Dept Precis Med, Naples, Italy.;AORN Colli Monaldi Hosp, Naples, Italy.
(författare)
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Iossa, DomenicoUniv Campania Luigi Vanvitelli, Dept Precis Med, Naples, Italy.;AORN Colli Monaldi Hosp, Naples, Italy.
(författare)
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Zusman, OrenBeilinson Med Ctr, Dept Med E, Rabin Med Ctr, Peta Tikva, Israel.
(författare)
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Friberg, LenaUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)lenasimo
(författare)
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Mouton, Johan W.Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands.
(författare)
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Theuretzbacher, UrsulaCtr Antiinfect Agents, Vienna, Austria.
(författare)
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Leibovici, LeonardTel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.;Beilinson Med Ctr, Dept Med E, Rabin Med Ctr, Peta Tikva, Israel.
(författare)
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Paul, MicalRambam Hlth Care Campus, Inst Infect Dis, Haifa, Israel.;Techion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Haifa, Israel.
(författare)
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Carmeli, YehudaTel Aviv Med Ctr & Sch Med, Natl Inst Infect Control & Antibiot Resistance, Tel Aviv, Israel.;Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
(författare)
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Tel Aviv Med Ctr & Sch Med, Natl Inst Infect Control & Antibiot Resistance, Tel Aviv, Israel.;Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.Tel Aviv Med Ctr & Sch Med, Natl Inst Infect Control & Antibiot Resistance, Tel Aviv, Israel.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinical Microbiology and Infection: Elsevier BV26:9, s. 1185-11911198-743X1469-0691
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Nutman, Amir
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Lellouche, Jonat ...
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Temkin, Elizabet ...
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Daikos, George
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Skiada, Anna
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Durante-Mangoni, ...
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Dishon-Benattar, ...
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Bitterman, Roni
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Yahav, Dafna
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Daitch, Vered
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Bernardo, Marian ...
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Iossa, Domenico
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Zusman, Oren
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Friberg, Lena
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Mouton, Johan W.
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Theuretzbacher, ...
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Leibovici, Leona ...
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Paul, Mical
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Carmeli, Yehuda
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