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Extracellular Vesic...
Extracellular Vesicles as Innovative Tool for Diagnosis, Regeneration and Protection against Neurological Damage
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- Andjus, Pavle (författare)
- Univ Belgrade, Fac Biol, Ctr Laser Microscopy, Belgrade 11000, Serbia
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- Kosanovic, Maja (författare)
- Univ Belgrade, INEP, Inst Applicat Nucl Energy, Belgrade 11080, Serbia
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- Milicevic, Katarina (författare)
- Univ Belgrade, Fac Biol, Ctr Laser Microscopy, Belgrade 11000, Serbia
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- Gautam, Mukesh (författare)
- Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA
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- Vainio, Seppo J. (författare)
- Univ Oulu, Fac Biochem & Mol Med, Dis Networks Res Unit, Univ Oulu Hosp, InfoTech Oulu, Kvantum Inst, Borealis Biobank North, FI-90014 Oulu, Finland
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- Jagecic, Denis (författare)
- Univ Zagreb, Sch Med, Croatian Inst Brain Res, Lab Stem Cells, HR-10000 Zagreb, Croatia
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- Kozlova, Elena (författare)
- Uppsala universitet,Kozlova: Regenerativ neurobiologi
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- Pivoriunas, Augustas (författare)
- State Res Inst Ctr Innovat Med, Dept Stem Cell Biol, LT-01001 Vilnius, Lithuania
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- Chachques, Juan-Carlos (författare)
- Univ Paris 05, Lab Biosurg Res, Alain Carpentier Fdn, Pompidu Hosp, F-75015 Paris, France
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- Sakaj, Mirena (författare)
- Ca Foscari Univ Venice, Dept Mol Sci & Nanosyst, I-30100 Venice, Italy
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- Brunello, Giulia (författare)
- Univ Padua, Dept Neurosci, I-35128 Padua, Italy
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- Mitrecic, Dinko (författare)
- Univ Zagreb, Sch Med, Croatian Inst Brain Res, Lab Stem Cells, HR-10000 Zagreb, Croatia
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- Zavan, Barbara (författare)
- Univ Ferrara, Dept Morphol Surg & Expt Med, I-44121 Ferrara, Italy
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(creator_code:org_t)
- 2020-09-18
- 2020
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 21:18
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Extracellular vesicles (EVs) have recently attracted a great deal of interest as they may represent a new biosignaling paradigm. According to the mode of biogenesis, size and composition, two broad categories of EVs have been described, exosomes and microvesicles. EVs have been shown to carry cargoes of signaling proteins, RNA species, DNA and lipids. Once released, their content is selectively taken up by near or distant target cells, influencing their behavior. Exosomes are involved in cell-cell communication in a wide range of embryonic developmental processes and in fetal-maternal communication. In the present review, an outline of the role of EVs in neural development, regeneration and diseases is presented. EVs can act as regulators of normal homeostasis, but they can also promote either neuroinflammation/degeneration or tissue repair in pathological conditions, depending on their content. Since EV molecular cargo constitutes a representation of the origin cell status, EVs can be exploited in the diagnosis of several diseases. Due to their capability to cross the blood-brain barrier (BBB), EVs not only have been suggested for the diagnosis of central nervous system disorders by means of minimally invasive procedures, i.e., "liquid biopsies", but they are also considered attractive tools for targeted drug delivery across the BBB. From the therapeutic perspective, mesenchymal stem cells (MSCs) represent one of the most promising sources of EVs. In particular, the neuroprotective properties of MSCs derived from the dental pulp are here discussed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- exosomes
- microvesicles
- drug delivery
- neurological disorders
- theragnostic blood-brain barrier
- stem cells
- neuronal development
- miRNA
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- ref (ämneskategori)
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- Av författaren/redakt...
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Andjus, Pavle
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Kosanovic, Maja
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Milicevic, Katar ...
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Gautam, Mukesh
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Vainio, Seppo J.
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Jagecic, Denis
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visa fler...
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Kozlova, Elena
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Pivoriunas, Augu ...
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Chachques, Juan- ...
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Sakaj, Mirena
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Brunello, Giulia
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Mitrecic, Dinko
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Zavan, Barbara
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